Declarative and procedural memory consolidation during sleep in patients with borderline personality disorder.

Full Abstract

Borderline personality disorder (BPD) is characterized by changes in subjective and objective measures of sleep quality. As recent findings point to the importance of sleep in memory consolidation, sleep-related memory consolidation was investigated in 15 female BPD patients (mean age 26.1+/-6.1 years) and 15 female healthy controls (mean age 25.6+/-6.8 years). Before and after the study night, declarative and procedural memory performance was tested by a paired associate list and a mirror tracing task. Subjective sleep quality was assessed by a sleep questionnaire, objective sleep quality was measured by a portable sleep recording device. During the study night the restorative value of sleep was significantly reduced in BPD patients (p<0.001), while objective sleep quality showed a trend for longer REM sleep duration (p=0.054). No significant differences were found regarding overnight performance improvement in the declarative and procedural memory tasks. Present findings suggest that declarative and procedural memory consolidation during sleep is intact in BPD patients.

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Author information

Author/s: Hornung, Orla P (OP); Regen, Francesca (F); Warnstedt, Claudia (C); Anghelescu, Ion (I); Danker-Hopfe, Heidi (H); Heuser, Isabella (I); Lammers, Claas-Hinrich (CH);

Affiliation: Department of Psychiatry and Psychotherapy, Charité-University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany. orla.hornung(-atsign-)charite.de

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of psychiatric research (J Psychiatr Res), published in England. (Language: eng)

Reference: 2008-Jul; vol 42 (issue 8) : pp 653-8

Dates: Created 2008/04/25; Completed 2008/08/01;

PMID: 17706671, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Borderline Personality Disorder - diagnosis; physiopathology; psychology
Circadian Rhythm - physiology
Control Groups
Electroencephalography - statistics & numerical data
Female
Humans
Memory - physiology

Paired-Associate Learning - physiology
Polysomnography - statistics & numerical data
Questionnaires
Sleep - physiology
Sleep Stages - physiology
Sleep, REM - physiology
Task Performance and Analysis
Verbal Learning - physiology

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