Extension of GnRH agonist through the luteal phase to improve the outcome of intracytoplasmic sperm injection.

Full Abstract

OBJECTIVE: To investigate the effect of continuous administration of gonadotropin-releasing hormone agonist (GnRHa) during the luteal phase in an intracytoplasmic sperm injection program. STUDY DESIGN: One hundred eighty-one women underwent a down-regulation protocol of GnRHa administered from the 21st day of the preceding cycle. Patients were randomized at initiation of stimulation by a computer-generated list. Group 1 patients (n = 90) were continuously administered GnRHa for 12 days after embryo transfer, while in group 2 patients GnRHa was stopped on the day of human chorionic gonadotropin administration. RESULTS: Demographic parameters, infertility etiologies, number of gonadotropin ampules used, number of mature oocytes recovered, rates of testicular sperm usage, number of embryos transferred, and cycle and transfer cancellation rates were similar in both groups. Clinical pregnancy rates, implantation rates and live birth rates did not show a significant difference. CONCLUSION: Extending GnRHa treatment through the luteal phase appeared not to have a significant impact on pregnancy or implantation rates in intracytoplasmic sperm injection cycles.

Author information

Author/s: Isikoglu, Mete (M); Ozgur, Kemal (K); Oehninger, Sergio (S);

Affiliation: Antalya IVF, Antalya, Turkey. misikoglu(-atsign-)hotmail.com

Journal and publication information

Publication Type: Journal Article; Randomized Controlled Trial

Journal: The Journal of reproductive medicine (J Reprod Med), published in United States. (Language: eng)

Reference: 2007-Jul; vol 52 (issue 7) : pp 639-44

Dates: Created 2007/09/12; Completed 2007/10/16;

PMID: 17847764, status: MEDLINE (last retrieved date: 2/18/2009)

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Adult
Embryo Implantation - drug effects
Embryo Transfer
Female
Fertility Agents, Female - pharmacology
Gonadotropin-Releasing Hormone - agonists
Humans
Leuprolide - pharmacology

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Fertility Agents, Female (0) ; Gonadotropin-Releasing Hormone (33515-09-2) ; Leuprolide (53714-56-0) ; Luteinizing Hormone (9002-67-9)

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