Research article summary (published 29 Sep 2007):

Altered performance of reelin-receptor ApoER2 deficient mice on spatial tasks using the Barnes maze.

Full Abstract

The apolipoprotein E receptor 2 (ApoER2), expressed predominantly in forebrain regions including the hippocampus, is 1 of 2 receptors for the extracellular matrix protein reelin, which is critical for cortical development. Previous studies of ApoER2 mutant mice have indicated deficits in synaptic plasticity and learning. The current authors assessed learning and memory of ApoER2 knockout and wild-type mice on the Barnes circular maze. Mice were trained in this task for 22 days, followed by memory recall and reversal tests. ApoER2 knockout mice were initially slower to complete the task, but by Day 22 they were more accurate than wild-type mice on several indices. There were no differences in memory assessed by the recall task, but ApoER2 knockout mice performed significantly worse on the memory reversal task. ApoER2 knockout mice also displayed altered use of specific search strategies and relationship of these strategies to errors made on the maze. (PsycINFO Database Record (c) 2007 APA, all rights reserved).

Author information

Author/s: Barr, Alasdair M (AM); MacLaurin, Sarah A (SA); Semenova, Svetlana (S); Fish, Kenneth N (KN); Markou, Athina (A);

Affiliation: Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

Grants: K01 MH064372 (Agency:NIMH NIH HHS) ; K01 MH064372-01 (Agency:NIMH NIH HHS) ; K01 MH064372-02 (Agency:NIMH NIH HHS) ; K01 MH064372-03 (Agency:NIMH NIH HHS) ; K01 MH064372-04 (Agency:NIMH NIH HHS) ; K01 MH064372-05 (Agency:NIMH NIH HHS) ; R01 MH62527 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Behavioral neuroscience (Behav Neurosci), published in United States. (Language: eng)

Reference: 2007-Oct; vol 121 (issue 5) : pp 1101-5

Dates: Created 2007/10/02; Completed 2007/11/20; Revised 2009/08/18;

PMID: 17907841, status: MEDLINE (last retrieval date: 8/21/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analysis of Variance Animals Cell Adhesion Molecules, Neuronal - deficiency; genetics Extracellular Matrix Proteins - deficiency; genetics Male Maze Learning - physiology Memory - physiology Memory, Short-Term - physiology Mental Recall - physiology

Mice Mice, Knockout Nerve Tissue Proteins - deficiency; genetics Neuronal Plasticity - genetics; physiology Psychomotor Performance - physiology Receptors, Lipoprotein - deficiency; genetics Reversal Learning - physiology Serine Endopeptidases - deficiency; genetics Space Perception - physiology

Associated Chemicals: Cell Adhesion Molecules, Neuronal (0) ; Extracellular Matrix Proteins (0) ; Nerve Tissue Proteins (0) ; Receptors, Lipoprotein (0) ; apolipoprotein E receptor 2 (0) ; Serine Endopeptidases (EC 3.4.21.-) ; reelin protein (EC 3.4.21.-)

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