Research article summary (published 30 Oct 2007):

Performance monitoring, error processing, and evaluative control following severe TBI.

Full Abstract

Patients with severe traumatic brain injury (TBI) often demonstrate impairments in performance monitoring--an evaluative control process that can be measured using the error-negativity/error-related negativity (Ne/ERN) and post-error positivity (Pe). The Ne/ERN and Pe are event-related potential (ERP) components generated following errors, with current theories suggesting the Ne/ERN reflects automatic performance monitoring and the Pe reflects error processing and awareness. To elucidate the electrophysiological mechanisms of performance monitoring deficits following severe TBI, behavioral and ERP measurements were obtained, whereas participants with severe TBI and neurologically-healthy comparison participants performed a modified color-naming version of the Stroop task. Behaviorally, both groups demonstrated robust response-time (RT) and error-rate interference. Participants with TBI exhibited generalized RT slowing; no significant between-groups interactions were present for RTs or error rates. ERP results indicate Ne/ERN amplitude was attenuated in participants with TBI, whereas the pattern of Pe amplitude did not clearly differentiate groups. Findings suggest the Ne/ERN as a potential electrophysiological marker of evaluative control/performance monitoring impairment following TBI. Implications for future research and potential clinical application as well as potential limitations in conducting electrophysiological research in neurologically-impaired populations are discussed.

Author information

Author/s: Larson, Michael J (MJ); Kaufman, David A S (DA); Schmalfuss, Ilona M (IM); Perlstein, William M (WM);

Affiliation: Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida 32610, USA.

Grants: F31 NS053335 (Agency:NINDS NIH HHS) ; K01 MH01857 (Agency:NIMH NIH HHS) ; R21 MH073076 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Journal of the International Neuropsychological Society : JINS (J Int Neuropsychol Soc), published in England. (Language: eng)

Reference: 2007-Nov; vol 13 (issue 6) : pp 961-71

Dates: Created 2007/10/18; Completed 2008/01/24;

PMID: 17942014, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent Adult Brain Injuries - physiopathology Brain Mapping Case-Control Studies Electroencephalography - methods Evoked Potentials - physiology Female Humans

Humans Male Mental Processes - physiology Middle Aged Neuropsychological Tests - statistics & numerical data Pattern Recognition, Visual - physiology Photic Stimulation - methods Psychomotor Performance - physiology Reaction Time - physiology

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