Research article summary (published 23 Oct 2007):

alpha4beta2-nicotinic receptor binding with 5-IA in Alzheimer's disease: methods of scan analysis.

Full Abstract

Five patients with Alzheimer's disease and five healthy volunteers were examined by SPECT with the nicotinic receptor ligand 123I-5-IA-85380. Patients were scanned before and after 6 weeks of treatment with donepezil. Quantification by regions of interest was reliable and the optimal normalisation procedure used cerebellar ratios. We found relative reductions in 5-IA binding capacity in patients in thalamus, frontal and central regions of interest of approximately one standard deviation unit (Cohen's d = 1). Reductions in binding after treatment with the acetylcholinesterase inhibitor donepezil of the same magnitude occurred in the brain stem. The study was clearly too small to confirm group differences, but it suggests that 5-IA can be used to examine both group differences and treatment effects in patients with Alzheimer's disease.

Author information

Author/s: Terrière, Emma (E); Sharman, Mike (M); Donaghey, Claire (C); Herrmann, Lucie (L); Lonie, Jane (J); Strachan, Marion (M); Dougall, Nadine (N); Best, Jonathan (J); Ebmeier, Klaus P (KP); Pimlott, Sally (S); Patterson, Jim (J); Wyper, David (D);

Affiliation: Division of Psychiatry, University of Edinburgh, Edinburgh, UK.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Neurochemical research (Neurochem Res), published in United States. (Language: eng)

Reference: 2008-Apr; vol 33 (issue 4) : pp 643-51

Dates: Created 2008/03/04; Completed 2008/06/03;

PMID: 17960479, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged Aged, 80 and over Alzheimer Disease - drug therapy; psychology; radionuclide imaging Azetidines - chemical synthesis; diagnostic use Brain - radionuclide imaging Cholinesterase Inhibitors - therapeutic use Female Humans Image Processing, Computer-Assisted Indans - therapeutic use

Male Neuropsychological Tests Nootropic Agents - therapeutic use Observer Variation Pilot Projects Piperidines - therapeutic use Pyridines - chemical synthesis; diagnostic use Radiopharmaceuticals - chemical synthesis; diagnostic use Receptors, Nicotinic - metabolism Tomography, Emission-Computed, Single-Photon

Associated Chemicals: 5-iodo-3-(2-azetidinylmethoxy)pyridine (0) ; Azetidines (0) ; Cholinesterase Inhibitors (0) ; Indans (0) ; Nootropic Agents (0) ; Piperidines (0) ; Pyridines (0) ; Radiopharmaceuticals (0) ; Receptors, Nicotinic (0) ; nicotinic receptor alpha4beta2 (0) ; donepezil (120011-70-3)

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