A polyacetylene compound from herbal medicine regulates genes associated with thrombosis in endothelial cells.

Full Abstract

From Toki-shakuyaku-san, an herbal formulation for 'cleansing stagnated blood,' a key gene regulatory compound was purified and identified through a screening based on DNA microarray and real-time PCR.

Author information

Author/s: Kawamura, Akira (A); Iacovidou, Maria (M); Takaoka, Anna (A); Soll, Clifford E (CE); Blumenstein, Michael (M);

Affiliation: Department of Chemistry, Hunter College of CUNY, 695 Park Avenue, New York, NY 10065, USA.

Grants: G12 RR003037-208120 (Agency:NCRR NIH HHS) ; G12 RR003037-210015 (Agency:NCRR NIH HHS) ; GM60654 (Agency:NIGMS NIH HHS) ; RR-03037 (Agency:NCRR NIH HHS) ; RR022649-01 (Agency:NCRR NIH HHS) ; S06 GM060654-050028 (Agency:NIGMS NIH HHS) ; S06 GM060654-060028 (Agency:NIGMS NIH HHS) ; S06 GM060654-070028 (Agency:NIGMS NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett), published in England. (Language: eng)

Reference: 2007-Dec; vol 17 (issue 24) : pp 6879-82

Dates: Created 2007/11/16; Completed 2008/01/18; Revised 2008/12/22;

PMID: 17964157, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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