[Clinical study on effect of Shenyin Oral Liquid in treating mild cognitive impairment]

Full Abstract

OBJECTIVE: To observe the therapeutic effect of Shenyin Oral Liquid (SOL) in relieving mild cognitive impairment (MCI) and decreasing the Alzheimer's disease (AD) transformation rate. METHODS: One hundred and seventeen MCI patients were randomly assigned to the Chinese medicine group (42 cases), the vitamin E group (38 cases) and the placebo group (37 cases). The treatment course was 12 months and a 6-month follow-up was conducted after ending the treatment course. RESULTS: After treatment, the scores of clock drawing test (CDT), nonsensical figure recognition and mini-mental state examination (MMSE) raised significantly in the Chinese medicine group (P < 0.05 or P < 0.01), the activity of acetylcholine esterase in erythrocytic membrane was lower in the Chinese medicine group than that in the placebo group and the Vitamin E group (P < 0.05 or P < 0.01). Six months after the treatment, there were 2 and 5 cases in the placebo group and the vitamin E group which were diagnosed as AD, respectively, and none in the Chinese medicine group. CONCLUSION: SOL has an effect similar to cholinesterase inhibitor, it could improve cognitive function in MCI patients and reduce the AD transformation rate in them.

Author information

Author/s: Zhou, Ru-Qian (RQ); Lin, Shui-Miao (SM); Yuan, Quan (Q);

Affiliation: Shanghai Geriatric Institute of Chinese Medicine, Shanghai. SGI-tcm(-atsign-)sohu.com

Journal and publication information

Publication Type: English Abstract; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban (Zhongguo Zhong Xi Yi Jie He Za Zhi), published in China. (Language: chi)

Reference: 2007-Sep; vol 27 (issue 9) : pp 793-5

Dates: Created 2007/10/30; Completed 2008/12/16;

PMID: 17969889, status: MEDLINE (last retrieved date: 2/18/2009)

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