Cognitive development of singletons born after intracytoplasmic sperm injection compared with in vitro fertilization and natural conception.

Full Abstract

OBJECTIVE:
To investigate cognitive development of singletons conceived by intracytoplasmic sperm injection (ICSI) at 5-8 years of age.

DESIGN:
Follow-up study.

SETTING:
University medical center, assessments between March 2004 and May 2005. PATIENT(S):
Singletons born between June 1996 and December 1999 after ICSI at the Leiden University Medical Center were compared with matched singletons born after IVF and natural conception (NC). INTERVENTION(S):
Mode of conception. MAIN OUTCOME MEASURE(S):
Intelligence quotient (IQ) was measured with the Revised Amsterdam Child Intelligence Test (short form). The investigators were blinded to conception mode. RESULT(S):
Singletons conceived by ICSI (n = 83) achieved lower IQ scores than IVF singletons (n = 83) (adjusted mean difference

IQ:
3.6 [95% confidence interval (CI) -0.8, 8.0]). After categorizing IQ outcomes (<85, 85-115, >115), no significant difference in the distribution of IQ was found. Singletons conceived by ICSI (n = 86) achieved lower IQ scores than NC singletons (n = 85); the adjusted mean difference varied between 5 and 7 points (5.6 [95% CI 0.9, 10.3]; 7.1 [95% CI 1.7, 12.5]) depending on the covariates included in the model. Adjustment for prematurity did not change the results. Percentages in IQ categories <85, 85-115, and >115 were 12%, 64%, and 24% for ICSI and 6%, 54%, and 40% for NC, respectively. CONCLUSION(S):
In the relatively limited sample investigated, cognitive development among ICSI singletons was lower than among IVF and NC singletons. Infertility factors or unmeasured confounders may play a role.

Learn Faster Today Improve your study skills

Author information

Author/s: Knoester, Marjolein (M); Helmerhorst, Frans M (FM); Vandenbroucke, Jan P (JP); van der Westerlaken, Lucette A J (LA); Walther, Frans J (FJ); Veen, Sylvia (S); Leiden Artificial Reproductive Techniques Follow-up Project;

Affiliation: Department of Pediatrics, Neonatal Center, Leiden University Medical Center, Leiden, The Netherlands.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Fertility and sterility (Fertil Steril), published in United States. (Language: eng)

Reference: 2008-Aug; vol 90 (issue 2) : pp 289-96

Dates: Created 2008/08/01; Completed 2008/08/14;

PMID: 17980875, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

These are the highest related articles currently in the database:

See 100+ related articles.