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| Research article summary (published 8 Jan 2008): |
A new fatty ester and a new triterpene from Skimmia laureola.
Full Abstract
Aerial parts of Skimmia laureola yielded a new fatty ester, (+)-skimmilaureol (1), and a new triterpene 16-29-dihydroxy, 20-ene cyclolaudenol (2). Five known compounds, namely, O-methyl-cyclolaudenol (3), (R)-7-methoxy-6-(3'-hydroxy-2'R-methoxy-3'-methyl butyl)coumarin (4), (+)-(S)-psi-ribalinine (5), (R)-(+)-ribalinine (6) and methyl isoplatydesmine (7), previously isolated from this plant were subjected to enzymatic bioassays for the first time. Compounds 3 and 4 were found to be prolyl endopeptidase inhibitors with IC(50) 8.21 +/- 0.407 and 39.63 +/- 1.502 microM, respectively, while compounds 5-7 were found to be acetyl-cholinesterase and butyryl-cholinesterase inhibitors with IC(50) 62.46 +/- 1.58, 153.31 +/- 1.9, 74.5 +/- 1.05 and 150.04 +/- 0.45, 12.99 +/- 0.31, 78.3 +/- 1.86 microM, respectively.
Author information
Author/s: Sultana, Nighat (N); Khalid, Asaad (A);
Affiliation: Pharmaceutical Research Center, PCSIR Laboratories Complex, Karachi, Pakistan. nighat2001us(-atsign-)yahoo.com
Journal and publication information
Publication Type: Journal Article
Journal: Natural product research (Nat Prod Res), published in England. (Language: eng)
Reference: 2008-Jan; vol 22 (issue 1) : pp 37-47
Dates: Created 2007/11/13; Completed 2008/04/24;
PMID: 17999337, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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