HLA-B*1301 as a biomarker for genetic susceptibility to hypersensitivity dermatitis induced by trichloroethylene among workers in China.

Full Abstract

BACKGROUND: Trichloroethylene (TCE) is used extensively as an industrial solvent and has been recognized as one of the major environmental pollutants. To date, > 200 cases of TCE-induced hypersensitivity dermatitis among exposed workers have been reported worldwide, and TCE exposure has become one of the critical occupational health issues in Asia. OBJECTIVES: The study aimed to identify genetic susceptible biomarkers associated with the TCE-induced hypersensitivity dermatitis in genes located in the human leukocyte antigen (HLA) region. METHODS: From 1998 to 2006, 121 cases with TCE-induced hypersensitivity dermatitis and 142 tolerant controls were recruited into the population-based case-control study. We determined HLA alleles B, DRB1, DQA1, and DQB1, by sequence-based typing. p-Values were corrected for comparisons of multiple HLA alleles. In addition, we compared and analyzed the structure character of amino acid residues of HLA molecules found in participants. RESULTS: We obtained complete genotyping data of 113 cases and 142 controls. The allele HLA-B*1301 was present in 83 (73.5%) of 113 patients compared with 13 (9.2%) of 142 tolerant workers (odds ratio = 27.5; 95% confidence interval, 13.5-55.7; corrected p = 1.48 x 10(-21)). In addition, the HLA-B*44 alleles were present in 6.2% (7/113) of patients, but were absent in TCE-tolerant workers. Residue 95 shared by HLA-B*1301 and HLA-B*44 molecules formed a different pocket F than other residues. CONCLUSIONS: The allele HLA-B*1301 is strongly associated with TCE-induced hypersensitivity dermatitis among exposed workers and might be used as a biomarker to predict high risk individuals to TCE.

Author information

Author/s: Li, Haishan (H); Dai, Yufei (Y); Huang, Hanlin (H); Li, Laiyu (L); Leng, Shuguang (S); Cheng, Juan (J); Niu, Yong (Y); Duan, Huawei (H); Liu, Qingjun (Q); Zhang, Xing (X); Huang, Xianqing (X); Xie, Jinxin (J); Feng, Zhiming (Z); Wang, Juncai (J); He, Jiaxi (J); Zheng, Yuxin (Y);

Affiliation: Key Laboratory, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Environmental health perspectives (Environ Health Perspect), published in United States. (Language: eng)

Reference: 2007-Nov; vol 115 (issue 11) : pp 1553-6

Dates: Created 2007/11/16; Completed 2008/01/17; Revised 2008/11/20;

PMID: 18007983, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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