Tricuspid regurgitant jet velocity is associated with hemolysis in children and young adults with sickle cell disease evaluated for pulmonary hypertension.

Full Abstract

Tricuspid regurgitant jet velocity (TRJV) >or= 2.5 m/sec. on echocardiography is a surrogate marker for pulmonary hypertension (PHT) in adults with sickle cell disease (SCD). We prospectively examined the relationship between TRJV and laboratory markers of hemolysis in 51 children and young adults with SCD at baseline. We found significant correlations between TRJV and lactate dehydrogenase (LDH), hemoglobin (Hb), reticulocyte count (retic) and aspartate aminotransferase (AST). LDH, retic and AST were significantly higher and Hb was lower in subjects with TRJV >or= 2.5 m/sec. We conclude that hemolysis significantly contributes to TRJV elevation in children and young adults with SCD.

Author information

Author/s: Liem, Robert I (RI); Young, Luciana T (LT); Thompson, Alexis A (AA);

Affiliation: Division of Hematology, Oncology & Stem Cell Transplant, Children's Memorial Hospital, 2300 Children's Plaza, Box 30, Chicago, IL 60614-3394, USA. rliem(-atsign-)childrensmemorial.org

Journal and publication information

Publication Type: Journal Article

Journal: Haematologica (Haematologica), published in Italy. (Language: eng)

Reference: 2007-Nov; vol 92 (issue 11) : pp 1549-52

Dates: Created 2007/11/20; Completed 2007/12/19;

PMID: 18024403, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: 18 Feb 2009 00:00:00)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.