Research article summary (published 19 Nov 2007):

A GluR1-cGKII interaction regulates AMPA receptor trafficking.

Full Abstract

Trafficking of AMPA receptors (AMPARs) is regulated by specific interactions of the subunit intracellular C-terminal domains (CTDs) with other proteins, but the mechanisms involved in this process are still unclear. We have found that the GluR1 CTD binds to cGMP-dependent protein kinase II (cGKII) adjacent to the kinase catalytic site. Binding of GluR1 is increased when cGKII is activated by cGMP. cGKII and GluR1 form a complex in the brain, and cGKII in this complex phosphorylates GluR1 at S845, a site also phosphorylated by PKA. Activation of cGKII by cGMP increases the surface expression of AMPARs at extrasynaptic sites. Inhibition of cGKII activity blocks the surface increase of GluR1 during chemLTP and reduces LTP in the hippocampal slice. This work identifies a pathway, downstream from the NMDA receptor (NMDAR) and nitric oxide (NO), which stimulates GluR1 accumulation in the plasma membrane and plays an important role in synaptic plasticity.

Author information

Author/s: Serulle, Yafell (Y); Zhang, Shuang (S); Ninan, Ipe (I); Puzzo, Daniela (D); McCarthy, Maria (M); Khatri, Latika (L); Arancio, Ottavio (O); Ziff, Edward B (EB);

Affiliation: Program in Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA.

Grants: 5 T32 GM 07308 (Agency:NIGMS NIH HHS) ; MH 067229 (Agency:NIMH NIH HHS) ; NS 049442 (Agency:NINDS NIH HHS) ; R01 MH067229-01 (Agency:NIMH NIH HHS) ; R01 MH067229-02 (Agency:NIMH NIH HHS) ; R01 MH067229-03 (Agency:NIMH NIH HHS) ; R01 MH067229-04 (Agency:NIMH NIH HHS) ; R01 MH067229-05 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Neuron (Neuron), published in United States. (Language: eng)

Reference: 2007-Nov; vol 56 (issue 4) : pp 670-88

Dates: Created 2007/11/22; Completed 2008/01/14; Revised 2008/12/02;

PMID: 18031684, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Catalytic Domain Cell Line Cells, Cultured Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors; metabolism Enzyme Inhibitors - pharmacology Hippocampus - metabolism; ultrastructure Humans Male Mice Mice, Inbred C57BL

Mice, Inbred C57BL Neuronal Plasticity - physiology Neurons - drug effects; metabolism; ultrastructure Organ Culture Techniques Phosphorylation Protein Binding - physiology Protein Transport - drug effects; physiology Rats Receptors, AMPA - metabolism Signal Transduction - drug effects; physiology Synaptic Transmission - physiology

Associated Chemicals: Enzyme Inhibitors (0) ; Receptors, AMPA (0) ; glutamate receptor ionotropic, AMPA 1 (0) ; Cyclic GMP-Dependent Protein Kinases (EC 2.7.1.37) ; cGMP-dependent protein kinase II (EC 2.7.10.-)

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