Objective versus subjective assessment of methylphenidate response.

Full Abstract

Subjective improvement-assessment in attention deficit/hyperactivity disorder (ADHD), following a single dose of methylphenidate (MPH) was compared to performance on the Test-of-Variables-of-Attention (TOVA). Self-perception was assessed with the clinical-global-impression-of-change (CGI-C). Participants included 165 ADHD subjects (M:F ratio 67%:33%) aged 5-18 (11.09 +/- 3.43) years. TOVA was administered before and after MPH challenge (0.3 mg/kg). Self-perception CGI-C scores were compared to the TOVA scores. An inverse correlation was found only between CGI-C and the TOVA-Commission-scores (r = -0.326, p < 0.001). We thus conclude that subjective reports are too unreliable to be used in order to assess MPH benefit in ADHD pediatric populations.

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Author information

Author/s: Manor, Iris (I); Meidad, Sheera (S); Zalsman, Gil (G); Zemishlany, Zvi (Z); Tyano, Sam (S); Weizman, Abraham (A);

Affiliation: ADHD Unit, Geha Mental Health Center, P.O. Box 102, Petach Tikva, 49100, Israel. imanor@clalit.org.il

Journal and publication information

Publication Type: Journal Article

Journal: Child psychiatry and human development (Child Psychiatry Hum Dev), published in United States. (Language: eng)

Reference: 2008-Sep; vol 39 (issue 3) : pp 273-82

Dates: Created 2008/06/12; Completed 2008/08/13;

PMID: 18058019, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Attention Deficit Disorder with Hyperactivity - diagnosis; drug therapy
Central Nervous System Stimulants - therapeutic use
Child
Child, Preschool
Female

Female
Humans
Male
Methylphenidate - therapeutic use
Self Concept
Severity of Illness Index

Associated Chemicals: Central Nervous System Stimulants (0) ; Methylphenidate (113-45-1)

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