Research article summary (published 28 Feb 2008):

Predictive value of angiogenic factors and uterine artery Doppler for early- versus late-onset pre-eclampsia and intrauterine growth restriction.

Full Abstract

OBJECTIVES: To investigate potential differences in the prediction of early- vs. late-onset pre-eclampsia and/or intrauterine growth restriction (PE/IUGR) by second-trimester uterine artery Doppler examination, and measurement of maternal serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt1). METHODS: Uterine artery mean pulsatility index (PI) and maternal serum PlGF and sFlt1 levels were measured at 24 weeks of gestation in 76 healthy pregnant women and 38 cases of PE/IUGR, of which 19 were defined as early onset (< 32 weeks). RESULTS: For a specificity of 95%, the sensitivities of uterine artery mean PI, PlGF and sFlt1 for early-onset PE/IUGR were 47.4%, 84.4% and 36.8%, respectively. When combining uterine artery Doppler with PlGF, the sensitivity for identifying early-onset PE/IUGR was 89.5% with a specificity of 95%. Conversely, the sensitivity for late-onset PE/IUGR was below 11% for all parameters analyzed. CONCLUSIONS: Angiogenic factors and uterine artery Doppler evaluation may be useful second-trimester screening tests for early-onset, but not late-onset, PE/IUGR. (c) 2007 ISUOG. Published by John Wiley & Sons, Ltd.

Author information

Author/s: Crispi, F (F); Llurba, E (E); Domínguez, C (C); Martín-Gallán, P (P); Cabero, L (L); Gratacós, E (E);

Affiliation: Department of Obstetrics, Fetal Medicine Unit, Barcelona, Spain.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (Ultrasound Obstet Gynecol), published in England. (Language: eng)

Reference: 2008-Mar; vol 31 (issue 3) : pp 303-9

Dates: Created 2008/03/05; Completed 2008/08/25;

PMID: 18058842, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Analysis of Variance Angiogenic Proteins - blood Area Under Curve Biological Markers - blood Case-Control Studies Female Fetal Growth Retardation - blood; diagnosis; ultrasonography Gestational Age Humans Infant, Newborn

Placental Circulation Pre-Eclampsia - blood; diagnosis; ultrasonography Predictive Value of Tests Pregnancy Pregnancy Proteins - blood Pregnancy Trimester, Second Pregnancy Trimester, Third Ultrasonography, Doppler - methods Ultrasonography, Prenatal - methods Uterus - blood supply; ultrasonography Vascular Endothelial Growth Factor Receptor-1 - blood

Associated Chemicals: Angiogenic Proteins (0) ; Biological Markers (0) ; Pregnancy Proteins (0) ; product placenta growth factor (144589-93-5) ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.1.112) ; FLT1 protein, human (EC 2.7.10.1)

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