Research article summary (published 6 Dec 2007):

Efficacy of tolterodine in relation to different urodynamic findings of detrusor overactivity.

Full Abstract

Aim of the study was to evaluate the efficacy of tolterodine in relation to different urodynamic findings of detrusor overactivity (DO). Women with urodynamic diagnosis of DO were prospectively included into two groups: with involuntary detrusor contractions during the cystometric filling phase (group 1) or after provocative manoeuvres (group 2). Tolterodine 4 mg ER was prescribed to all women. Drug efficacy was assessed using a 3-point scale. Women were defined responders if they were improved/cured after 3 months of therapy, and non-responders if symptoms did not change. The outcome of therapy was compared between groups. A total of 111 women were included. The groups did not differ for demographic characteristics. After 12 weeks, we found a significant difference (P = 0.0008) between groups in terms of tolterodine efficacy with a better response rate in group 1. Our study shows that tolterodine efficacy may be related to different urodynamic findings of DO.

Author information

Author/s: Salvatore, Stefano (S); Serati, Maurizio (M); Digesu, G Alessandro (GA); Triacca, Paola (P); Uccella, Stefano (S); Khullar, Vik (V); Bolis, PierFrancesco (P);

Affiliation: Urogynaecology Unit, University of Insubria, Del Ponte Hospital, Varese, Italy. stefanosalvatore(-atsign-)hotmail.com

Journal and publication information

Publication Type: Comparative Study; Journal Article

Journal: International urogynecology journal and pelvic floor dysfunction (Int Urogynecol J Pelvic Floor Dysfunct), published in England. (Language: eng)

Reference: 2008-May; vol 19 (issue 5) : pp 701-4

Dates: Created 2008/04/08; Completed 2008/08/19; Revised 2009/10/21;

PMID: 18066482, status: MEDLINE (last retrieval date: 10/21/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent Adult Aged Aged, 80 and over Benzhydryl Compounds - therapeutic use Body Mass Index Cresols - therapeutic use Female Follow-Up Studies

Follow-Up Studies Humans Middle Aged Muscarinic Antagonists - therapeutic use Phenylpropanolamine - therapeutic use Prospective Studies Treatment Outcome Urinary Bladder, Overactive - drug therapy; physiopathology Urodynamics - drug effects; physiology

Associated Chemicals: Benzhydryl Compounds (0) ; Cresols (0) ; Muscarinic Antagonists (0) ; tolterodine (124937-51-5) ; Phenylpropanolamine (14838-15-4)

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