Neuropsychology and clinical neuroscience of persistent post-concussive syndrome.

Full Abstract

On the mild end of the acquired brain injury spectrum, the terms concussion and mild traumatic brain injury (mTBI) have been used interchangeably, where persistent post-concussive syndrome (PPCS) has been a label given when symptoms persist for more than three months post-concussion. Whereas a brief history of concussion research is overviewed, the focus of this review is on the current status of PPCS as a clinical entity from the perspective of recent advances in the biomechanical modeling of concussion in human and animal studies, particularly directed at a better understanding of the neuropathology associated with concussion. These studies implicate common regions of injury, including the upper brainstem, base of the frontal lobe, hypothalamic-pituitary axis, medial temporal lobe, fornix, and corpus callosum. Limitations of current neuropsychological techniques for the clinical assessment of memory and executive function are explored and recommendations for improved research designs offered, that may enhance the study of long-term neuropsychological sequelae of concussion.

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Author information

Author/s: Bigler, Erin D (ED);

Affiliation: Department of Psychology, Brigham Young University, Provo, Utah 84602, USA. erin_bigler@byu.edu

Grants: 1 R01 HD048946-01A2 (Agency:United States NICHD)

Journal and publication information

Publication Type: Historical Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

Journal: Journal of the International Neuropsychological Society : JINS (J Int Neuropsychol Soc), published in England. (Language: eng)

Reference: 2008-Jan; vol 14 (issue 1) : pp 1-22

Dates: Created 2007/12/14; Completed 2008/06/20;

PMID: 18078527, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Humans
Neuropsychology
Neurosciences
Post-Concussion Syndrome - history; pathology; physiopathology; psychology
Severity of Illness Index

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