Decreased CD4+CD25+bright T cells in peripheral blood of patients with primary Sjogren's syndrome.

Full Abstract

CD4+CD25+bright T cells played a crucial role in the suppression of immune response. Recently, decreased levels of CD4+CD25+bright T cells in the peripheral blood of patients with systemic lupus erythematosus were reported, suggesting the potential role of CD4+CD25+bright T cells in human autoimmune diseases. Primary Sjögren's syndrome (pSS) is another common human systemic autoimmune disease. The present study aimed to investigate the levels of CD4+CD25+bright T cells in pSS and to correlate their levels with some biomarkers of inflammation and immune activation. Thirty-three patients with pSS and 35 age- and sex-matched normal individuals were enrolled in the study. The flowcytometric method was applied in the measurement of CD4+CD25+bright T cells. The results showed that patients with pSS had statistically lower levels of CD4+CD25+bright T cells than normal controls, expressed either as absolute cell numbers (mean+/-SD:
47.07+/-25.53 cells/mm3 versus 79.55+/-34.56 cells/mm3, P<0.001) or as percentages of peripheral blood mononuclear cells (mean+/-SD:
2.79+/-1.06% versus 3.84+/-1.42%, P<0.001) or as percentages of CD4+ T cells (mean+/-SD:
7.85+/-2.62% versus 11.68+/-3.78%, P<0.005). Moreover, there were statistically significant inverse correlations between the levels of CD4+CD25+bright T cells and some parameters of inflammation or immune activation including erythrocyte sedimentation rate, C-reactive protein, IgG and rheumatoid factors. The result suggested that CD4+CD25+bright T cells were likely to play anti-inflammatory and immunosuppressive roles in the pathogenesis of pSS. However, the exact functions of decreased circulating CD4+CD25+bright T cells in pSS need further elucidated.

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Author information

Author/s: Liu, M-F (MF); Lin, L-H (LH); Weng, C-T (CT); Weng, M-Y (MY);

Affiliation: Section of Rheumatology and Immunology, Department of Internal Medicine, Medical College, National Cheng Kung University, Tainan, Taiwan, Republic of China. mfliu@mail.ncku.edu.tw

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Lupus (Lupus), published in England. (Language: eng)

Reference: 2008-; vol 17 (issue 1) : pp 34-9

Dates: Created 2007/12/19; Completed 2008/04/29;

PMID: 18089681, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Aged
Aged, 80 and over
Blood Sedimentation
C-Reactive Protein - metabolism
CD4-Positive T-Lymphocytes - immunology
Case-Control Studies
Down-Regulation
Female
Flow Cytometry

Flow Cytometry
Humans
Immunoglobulin G - blood
Inflammation - blood; immunology
Interleukin-2 Receptor alpha Subunit - analysis
Male
Middle Aged
Rheumatoid Factor - blood
Sjogren's Syndrome - blood; immunology
T-Lymphocytes, Regulatory - immunology

Associated Chemicals: Immunoglobulin G (0) ; Interleukin-2 Receptor alpha Subunit (0) ; C-Reactive Protein (9007-41-4) ; Rheumatoid Factor (9009-79-4)

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