[Characterization of stem cells from the murine adult mammary gland]

(Vers la caractérisation des cellules souches de la glande mammaire murine adulte.)

Full Abstract

The postnatal mammary morphogenesis comprises two steps, first, formation of a system of branching ducts at puberty and second, alveologenesis during pregnancy. The mammary epithelium is organized as a bilayer, composed of two cellular types, basal myoepithelial and luminal epithelial. The remarkable regenerative properties revealed in serial transplantation experiments suggest that the adult mammary epithelium harbors stem cells. Various strategies including analysis of DNA label-retaining cells, transgenic approach, and in vivo transplantation assay, have been used to isolate and characterize murine mammary stem and progenitor cells. Their molecular characteristics remain to be defined precisely but notable progress have been already made in the enrichment and identification of these cells. Current studies favor the hypothesis of a basal-type mammary stem cells expressing high levels of alpha 6, beta1 and beta 3 integrin chains, the major receptors of extracellular matrix proteins. Luminal-type progenitors may participate in the establishment of the bilayered alveolar epithelium during pregnancy.

Author information

Author/s: Deugnier, Marie-Ange (MA); Petit, Valérie (V); Taddéi-De La Hosseraye, Ilaria (I); Faraldo, Marisa (M); Glukhova, Marina A (MA);

Affiliation: Equipe Mécanismes moléculaires du développement de la glande mammaire, Institut Curie, CNRS UMR144, 26, rue d'Ulm, 75248 Paris Cedex 05, France. Marie-Ange.Deugnier(-atsign-)curie.fr

Journal and publication information

Publication Type: English Abstract; Journal Article; Review

Journal: Médecine sciences : M/S (Med Sci (Paris)), published in France. (Language: fre)

Reference: 2007-Dec; vol 23 (issue 12) : pp 1125-31

Dates: Created 2007/12/24; Completed 2008/02/27;

PMID: 18154715, status: MEDLINE (last retrieved date: 2/18/2009)

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