Research article summary (published 19 Dec 2007):

[Methylphenidate of retard forms in children and adolescents with ADHD - an overview]

(Methylphenidat-Retard-Präparate bei Kindern und Jugendlichen mit ADHs - eine Ubersicht.)

Full Abstract

As yet, stimulants remain the preferred means of treating attention-deficit/hyperactivity disorder (ADHD) pharmacologically. They are indicated when measures based on behavioural therapy or psychoeducation alone are not sufficient. How-ever, the period of effectiveness of immediate release stimulants is often not satisfactory. A variety of retarded forms of methylphenidate have now been developed and approved for the German market. This paper presents an overview of clinical studies on effectiveness, period of effectiveness and the profile of side effects of different forms stimulants available in Germany. In clinical practice, the new retard products represent effective alternatives. There is an advantage in administering this drug in a once-daily single dose. At the same time, the side effects that are caused by an extended period of effectiveness have to be studied in detail. A more precise adaptation to the daily obligations and needs of children and adolescents is needed. Possibly, a combination with unretareded MPH might lead to a better effect/side-effect profile.

Author information

Author/s: Pelz, R (R); Banaschewski, T (T); Becker, K (K);

Affiliation: Klinik für Psychiatrie und Psychotherapie des Kindes- und Jugendalters am Zentralinstitut für Seelische Gesundheit, Mannheim. reta.pelz(-atsign-)zi-mannheim.de

Journal and publication information

Publication Type: Comparative Study; English Abstract; Journal Article; Review

Journal: Klinische Pädiatrie (Klin Padiatr), published in Germany. (Language: ger)

Reference: -2008 Mar-Apr; vol 220 (issue 2) : pp 93-100

Dates: Created 2008/03/12; Completed 2008/06/05;

PMID: 18157763, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent Adult Age Factors Amphetamine - therapeutic use Attention Deficit Disorder with Hyperactivity - drug therapy; economics Central Nervous System Stimulants - administration & dosage; adverse effects; blood; economics; therapeutic use Child Delayed-Action Preparations Dextroamphetamine - therapeutic use

Dextroamphetamine - therapeutic use Drug Therapy, Combination Female Germany Humans Male Methylphenidate - administration & dosage; adverse effects; blood; economics; pharmacokinetics; therapeutic use Practice Guidelines as Topic Substance-Related Disorders - etiology

Associated Chemicals: Central Nervous System Stimulants (0) ; Delayed-Action Preparations (0) ; Methylphenidate (113-45-1) ; Amphetamine (300-62-9) ; Dextroamphetamine (51-64-9)

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