Research article summary (published 19 Nov 2007):

Long-term monoamine changes in the striatum and nucleus accumbens after acute chlorpyrifos exposure.

Full Abstract

This study examined the time-course effects (2, 7, 14 and 30 days) of acute chlorpyrifos (CPF) intoxication (250 mg/kg, s.c.) on monoamine systems and acetylcholinesterase (AChE) activity in the striatum and nucleus accumbens of adult male rats. We show that CPF produced significant long-term inhibition of AChE activity in the striatum and nucleus accumbens. In the striatum, CPF intoxication resulted in changes in dopamine (DA) metabolism after 2 days and changes in serotonin (5-HT) turnover after 7 and 15 days. Significant decreases in monoamine content including norepinephrine (NE), DA, 5-HT and their metabolites were found in the nucleus accumbens 30 days after CPF intoxication. These results suggest that acute exposure to CPF induces long-term changes in the monoamine systems (NE, DA and 5-HT) in adult animals. The lack of correlation between regional AChE activity and neurochemical outcomes points to independent mechanisms.

Author information

Author/s: Moreno, Margarita (M); Cañadas, Fernando (F); Cardona, Diana (D); Suñol, Cristina (C); Campa, Leticia (L); Sánchez-Amate, Maria Carmen (MC); Flores, Pilar (P); Sanchez-Santed, Fernando (F);

Affiliation: Departamento de Neurociencia y Ciencias de la Salud, Universidad de Almería, Crta. Sacramento s/n, 04120 La Cañada de San Urbano, Almería 04120, Spain.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Toxicology letters (Toxicol Lett), published in Netherlands. (Language: eng)

Reference: 2008-Jan; vol 176 (issue 2) : pp 162-7

Dates: Created 2008/01/07; Completed 2008/04/24;

PMID: 18164878, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

3,4-Dihydroxyphenylacetic Acid - metabolism Acetylcholine - metabolism Analysis of Variance Animals Behavior, Animal - drug effects Biogenic Monoamines - metabolism Body Temperature - drug effects Chlorpyrifos - administration & dosage; toxicity Corpus Striatum - drug effects; metabolism Dopamine - metabolism Homovanillic Acid - metabolism Hydroxyindoleacetic Acid - metabolism

Hydroxyindoleacetic Acid - metabolism Injections, Subcutaneous Insecticides - administration & dosage; toxicity Male Motor Activity - drug effects Norepinephrine - metabolism Nucleus Accumbens - drug effects; metabolism Rats Rats, Wistar Serotonin - metabolism Time Factors Weight Gain - drug effects

Associated Chemicals: Biogenic Monoamines (0) ; Insecticides (0) ; 3,4-Dihydroxyphenylacetic Acid (102-32-9) ; Chlorpyrifos (2921-88-2) ; Homovanillic Acid (306-08-1) ; Serotonin (50-67-9) ; Norepinephrine (51-41-2) ; Dopamine (51-61-6) ; Acetylcholine (51-84-3) ; Hydroxyindoleacetic Acid (54-16-0)

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