Relationship of ferritin to symptom ratings children with attention deficit hyperactivity disorder: effect of comorbidity.

Full Abstract

Our aim was to investigate the relation between behavioral symptoms and hematological variables which are related with iron deficiency and anemia, ferritin, hemoglobin, mean corpuscular volume (MCV), and reticulosite distribution width (RDW) in children and adolescents with pure Attention Deficit Hyperactivity Disorder (ADHD) or ADHD comorbid with other psychiatric disorders. The sample consisted of 151 subjects with ADHD, 45 of these subjects had other comorbid conditions. Conners Parent (CPRS) and Teacher Rating Scales (CTRS) were obtained. Comorbid ADHD subjects had lower mean hemoglogin and MCV. In the ADHD group in general, CPRS and CTRS Total scores were significantly negatively correlated with ferritin level. When only pure ADHD subjects were taken into account, the correlations did not reach statistical significance. Overall, these results suggested that lower ferritin level was associated with higher behavioral problems reported by both parents and teachers. Presence of comorbid conditions might increase the effect of lower iron stores on behavioral measures.

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Author information

Author/s: Oner, Pinar (P); Oner, Ozgur (O);

Affiliation: Child Psychiatry Department, Ataturk Hospital, Ankara, Turkey. pinaryoner@yahoo.com

Grants: D43TW05807 (Agency:United States FIC)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Child psychiatry and human development (Child Psychiatry Hum Dev), published in United States. (Language: eng)

Reference: 2008-Sep; vol 39 (issue 3) : pp 323-30

Dates: Created 2008/06/12; Completed 2008/08/13;

PMID: 18165896, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Anemia, Iron-Deficiency - blood; epidemiology
Attention Deficit Disorder with Hyperactivity - blood; epidemiology
Blood Chemical Analysis
Child
Child, Preschool

Comorbidity
Female
Ferritins - blood
Humans
Male
Observer Variation

Associated Chemicals: Ferritins (9007-73-2)

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