Transient and sustained brain activity during anticipatory visuospatial attention.

Full Abstract

In this study, we determined whether the visuospatial attention network of frontal, parietal, and occipital cortex can be parsed into two different subsets of active regions associated with transient and sustained processes within the same cue-to-target delay period of an endogenously cued visuospatial attention task. We identified regions with early transient activity and regions with later sustained activity during the same trials using a general linear model analysis of event-related BOLD functional MRI data with two timecourse covariates for the same cue-to-target delay period. During the delay between the cue and target, we observed significant transient activity in right frontal eye field and right occipital-parietal junction, and significant sustained activity in right ventral intraparietal sulcus and right dorsolateral and anterior prefrontal cortex.

Author information

Author/s: Luks, Tracy L (TL); Sun, Felice T (FT); Dale, Corby L (CL); Miller, William L (WL); Simpson, Gregory V (GV);

Affiliation: Department of Radiology, University of California San Francisco, San Francisco, California 94143, USA. Tracy.Luks(-atsign-)radiology.ucsf.edu

Grants: AG027369 (Agency:NIA NIH HHS) ; MH064295 (Agency:NIMH NIH HHS) ; NS27900 (Agency:NINDS NIH HHS) ; NS45171 (Agency:NINDS NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Neuroreport (Neuroreport), published in England. (Language: eng)

Reference: 2008-Jan; vol 19 (issue 2) : pp 155-9

Dates: Created 2008/01/10; Completed 2008/03/24;

PMID: 18185100, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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