Research article summary (published 8 Jan 2008):

Diagnosis and management of HIV drug hypersensitivity.

Full Abstract

Drug hypersensitivity reactions are an important cause of morbidity in HIV-infected patients who take complex medication regimens. Correct diagnosis and management of these reactions are essential in the clinical care of HIV disease. Trimethoprim-sulfamethoxazole, abacavir, nevirapine, atazanavir, and enfuvirtide can all cause hypersensitivity rashes. In this review, we discuss the evidence for immunologic mechanisms of hypersensitivity reactions to HIV medications, the clinical characteristics of these reactions, and guidelines that currently exist for their identification and management.

Author information

Author/s: Davis, Carla M (CM); Shearer, William T (WT);

Affiliation: Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030-2399, USA. cmdavis(-atsign-)texaschildrenshospital.org

Grants: A169441 (Agency:PHS HHS) ; AI27551 (Agency:NIAID NIH HHS) ; AI36211 (Agency:NIAID NIH HHS) ; HD41983 (Agency:NICHD NIH HHS) ; HD78522 (Agency:NICHD NIH HHS) ; HD79533 (Agency:NICHD NIH HHS) ; HL72705 (Agency:NHLBI NIH HHS) ; RR0188 (Agency:NCRR NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

Journal: The Journal of allergy and clinical immunology (J Allergy Clin Immunol), published in United States. (Language: eng)

Reference: 2008-Apr; vol 121 (issue 4) : pp 826-832.e5

Dates: Created 2008/04/08; Completed 2008/06/17;

PMID: 18190954, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Anti-Bacterial Agents - adverse effects; metabolism Anti-HIV Agents - adverse effects; metabolism Drug Hypersensitivity - diagnosis; immunology; therapy; virology Exanthema - diagnosis; immunology; therapy; virology

HIV Infections - complications; drug therapy; immunology; therapy Humans Immunosuppressive Agents - adverse effects; metabolism Practice Guidelines as Topic

Associated Chemicals: Anti-Bacterial Agents (0) ; Anti-HIV Agents (0) ; Immunosuppressive Agents (0)

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