Kaposi's sarcoma herpes virus taps into a host microRNA regulatory network.

Full Abstract

Kaposi's sarcoma-associated herpes virus (KSHV), the causative agent of several neoplasms, has recently been shown to encode 12 microRNAs. mir-155 is a host-encoded microRNA associated with lymphomagenesis. Two new papers provide strong evidence that a KSHV-encoded microRNA and mir-155 share a common set of mRNA targets and binding sites, implying a possible link between viral- and non-viral-mediated tumorigenesis.

Author information

Author/s: McClure, Lydia V (LV); Sullivan, Christopher S (CS);

Affiliation: Molecular Genetics and Microbiology, The University of Texas at Austin, 1 University Station A5000, Austin, TX 78712-0162, USA.

Journal and publication information

Publication Type: Journal Article

Journal: Cell host & microbe (Cell Host Microbe), published in United States. (Language: eng)

Reference: 2008-Jan; vol 3 (issue 1) : pp 1-3

Dates: Created 2008/01/14; Completed 2008/02/25; Revised 2008/09/19;

PMID: 18191785, status: MEDLINE (last retrieved date: 2/18/2009)

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