Research article summary (published 26 Jan 2008):

Distinct single but not necessarily repeated tetanization is required to induce hippocampal late-LTP in the rat CA1.

Full Abstract

The protein synthesis-dependent form of hippocampal long-term potentiation (late-LTP) is thought to underlie memory. Its induction requires a distinct stimulation strength, and the common opinion is that only repeated tetani result in late-LTP whereas as single tetanus only reveals a transient early-LTP. Properties of LTP induction were compared to learning processes where repetition is often the prerequisite for a long-lasting memory. However, also single events can lead to manifested memory. If LTP subserves processes of learning, similar results should be detectable for LTP. Here we show that a single tetanus is sufficient to induce late-LTP requiring dopaminergic co-transmission during induction.

Author information

Author/s: Sajikumar, Sreedharan (S); Navakkode, Sheeja (S); Frey, Julietta U (JU);

Affiliation: Department for Neurophysiology, Leibniz Institute for Neurobiology, D-39118 Magdeburg, Germany.

Journal and publication information

Publication Type: Comparative Study; In Vitro; Journal Article

Journal: Learning & memory (Cold Spring Harbor, N.Y.) (Learn Mem), published in United States. (Language: eng)

Reference: 2008-Feb; vol 15 (issue 2) : pp 46-9

Dates: Created 2008/01/30; Completed 2008/02/20; Revised 2008/11/21;

PMID: 18230671, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Anisomycin - pharmacology Benzazepines - pharmacology Dopamine Antagonists - pharmacology Electric Stimulation - methods Emetine - pharmacology Hippocampus - physiology Learning - physiology Long-Term Potentiation - drug effects; physiology Male

Male Memory - physiology Protein Synthesis Inhibitors - pharmacology Rats Rats, Wistar Receptors, Dopamine D1 - physiology Receptors, Dopamine D5 - physiology Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Synapses - physiology Valine - analogs & derivatives; pharmacology

Associated Chemicals: Benzazepines (0) ; Dopamine Antagonists (0) ; Protein Synthesis Inhibitors (0) ; Receptors, Dopamine D1 (0) ; Receptors, N-Methyl-D-Aspartate (0) ; Receptors, Dopamine D5 (137750-35-7) ; Anisomycin (22862-76-6) ; Emetine (483-18-1) ; Valine (7004-03-7) ; 2-amino-5-phosphopentanoic acid (76326-31-3)

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