Research article summary (published 2008):

Spermine attenuates behavioral and biochemical alterations induced by quinolinic acid in the striatum of rats.

Full Abstract

Polyamines are aliphatic amines containing nucleophilic centers that are found in all eukaryotic cells, including brain cells. These compounds determine neuroprotection in experimental models of cerebral ischemia and neurotoxicity. In the current study we investigated the protective effects of spermine, an agonist of the polyamine binding site at the N-methyl-d-aspartate receptor, against the behavioral and neurochemical alterations induced by quinolinic acid. The unilateral intrastriatal injection of quinolinic acid (180 nmol/site into the dorsal striatum) induced stereotypical motor asymmetries, assessed by the open field and elevated body swing tests. Spermine modulated quinolinic acid-induced rotational behavior biphasically. While the previous intrastriatal administration of spermine at the dose of 0.1 nmol/site increased, the administration of spermine at the dose of 10 nmol/site reduced quinolinic acid-induced rotational behavior. Spermine (10 nmol/site) also decreased the contralateral swing behavior induced by quinolinic acid. Furthermore, the effect of 10 nmol of spermine was counteracted by the co-administration of arcaine (10 nmol), a selective antagonist of the polyamine binding site at the N-methyl-d-aspartate receptor. In addition, spermine (10 nmol) protected against quinolinic acid-induced protein carbonylation in the rat striatum, further suggesting an antioxidant role for this polyamine. These results provide evidence that the behavioral and biochemical alterations induced by quinolinic acid are attenuated or prevented by spermine through its interaction with N-methyl-d-aspartate receptor and/or its antioxidant function.

Author information

Author/s: Velloso, Nádia Aléssio (NA); Dalmolin, Gerusa Duarte (GD); Fonini, Graciela (G); Gindri Sinhorin, Valéria Dornelles (VD); Ferreira da Silveira, Aron (A); Rubin, Maribel Antonello (MA); Mello, Carlos Fernando (CF);

Affiliation: Department of Chemistry, Center of Exact and Natural Sciences, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Brain research (Brain Res), published in Netherlands. (Language: eng)

Reference: 2008-Mar; vol 1198 (issue ) : pp 107-14

Dates: Created 2008/02/25; Completed 2008/06/02;

PMID: 18243165, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Antioxidants - metabolism; pharmacology Behavior, Animal - drug effects; physiology Biguanides - pharmacology Binding Sites - drug effects; physiology Binding, Competitive - drug effects; physiology Brain Chemistry - drug effects; physiology Corpus Striatum - drug effects; metabolism Dose-Response Relationship, Drug

Excitatory Amino Acid Antagonists - pharmacology Male Motor Activity - drug effects; physiology Oxidative Stress - drug effects; physiology Quinolinic Acids - antagonists & inhibitors; pharmacology Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - drug effects; metabolism Spermine - metabolism; pharmacology

Associated Chemicals: Antioxidants (0) ; Biguanides (0) ; Excitatory Amino Acid Antagonists (0) ; Quinolinic Acids (0) ; Receptors, N-Methyl-D-Aspartate (0) ; arcaine (544-05-8) ; Spermine (71-44-3)

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