Elevated 3T proton MRS glutamate levels associated with poor Continuous Performance Test (CPT-0X) scores and genetic risk for schizophrenia.

Full Abstract

Glutamate was quantified by proton magnetic resonance spectroscopy ((1)H-MRS) in the medial frontal lobes of 15 adult siblings of individuals with schizophrenia (HR) and 14 healthy volunteers (HV), all of whom also completed a Continuous Performance Test (CPT). Subjects were free of psychopathology but the HR group showed greater variability in glutamate levels. After median stratification, the high glutamate group contained a larger proportion of HR than HV subjects and scored lower on the CPT. Elevated glutamate may relate to poor sustained attention and elevated risk of schizophrenia, suggesting a potential role for glutamate in an endophenotype for schizophrenia.

Author information

Author/s: Purdon, Scot E (SE); Valiakalayil, Agitha (A); Hanstock, Christopher C (CC); Seres, Peter (P); Tibbo, Philip (P);

Affiliation: Bebensee Schizophrenia Research Unit, Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada. spurdon(-atsign-)ualberta.ca

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Schizophrenia research (Schizophr Res), published in Netherlands. (Language: eng)

Reference: 2008-Feb; vol 99 (issue 1-3) : pp 218-24

Dates: Created 2008/02/22; Completed 2008/05/27;

PMID: 18248960, status: MEDLINE (last retrieved date: 2/18/2009)

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