Biomonitoring of mercury in patients with complaints attributed to dental amalgam, healthy amalgam bearers, and amalgam-free subjects: a diagnostic study.

Full Abstract

OBJECTIVE: To investigate the suitability of measurements of mercury (Hg) concentration as a means of identifying patients with health complaints attributed to dental amalgam. METHODS: Hg in erythrocytes, plasma, urine, and saliva was determined in 27 patients complaining about health problems attributed to amalgam, 27 healthy volunteers with amalgam fillings, and 27 healthy amalgam-free volunteers. RESULTS: Concentrations of inorganic mercury in blood and of total mercury in urine and saliva differed significantly between individuals with amalgam fillings and amalgam-free volunteers, but not between symptomatic patients and healthy volunteers with amalgam fillings. Urine Hg levels tended to be better correlated with blood than with saliva data. Levels of organic Hg were equal in all groups. CONCLUSION: Concentrations of total and inorganic mercury in body fluids do not distinguish between asymptomatic amalgam bearers and those who suffer from a poorly defined syndrome of multiple nonspecific symptoms.

Author information

Author/s: Melchart, Dieter (D); Köhler, Wolfgang (W); Linde, Klaus (K); Zilker, Thomas (T); Kremers, Leo (L); Saller, Reinhard (R); Halbach, Stefan (S);

Affiliation: Technical University Munich, Munich, Germany. dieter.melchart(-atsign-)lrz.tum.de

Journal and publication information

Publication Type: Journal Article

Journal: Clinical toxicology (Philadelphia, Pa.) (Clin Toxicol (Phila)), published in United States. (Language: eng)

Reference: 2008-Feb; vol 46 (issue 2) : pp 133-40

Dates: Created 2008/02/08; Completed 2008/05/15; Revised 2009/11/17;

PMID: 18259961, status: MEDLINE (last retrieved date: 11/17/2009)

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