Research article summary (published 23 Feb 2008):

Cortical auditory dysfunction in benign rolandic epilepsy.

Full Abstract

PURPOSE: To evaluate cortical auditory function, including speech recognition, in children with benign rolandic epilepsy (BRE). METHODS: Fourteen children, seven patients with BRE and seven matched controls, underwent audiometric and behavioral testing, simultaneous EEG recordings, and auditory-evoked potential recordings with speech and tones. Speech recognition was tested under multiple listening conditions. RESULTS: All participants demonstrated normal speech recognition abilities in quiet, as well as normal peripheral and subcortical auditory function. BRE patients performed significantly worse than controls when speech recognition was tested under adverse listening conditions, including background noise. Five BRE patients who were impaired on two or more tests had centrotemporal spiking on awake EEG. There were no significant group differences in the latency or amplitude of early N100 cortical responses to speech or tones. Conversely, the mismatch negativity, a preattentive index of cortical processing that is elicited passively, was absent or prolonged for speech, but not tones, in BRE patients as compared to controls. DISCUSSION: Children with BRE demonstrated specific speech recognition impairments. Our evoked potential findings indicate that these behavioral impairments reflect dysfunction of nonprimary auditory cortex and cannot be attributed solely to attention difficulties. A possible association between auditory impairments and centrotemporal spiking (>1/min) on awake EEG was identified. The pattern of speech recognition impairments observed is a known risk factor for academic difficulties in school-age children. Our results underscore the importance of comprehensive auditory testing, using behavioral and electrophysiological measures, in children with BRE.

Author information

Author/s: Boatman, Dana F (DF); Trescher, William H (WH); Smith, Cynthia (C); Ewen, Joshua (J); Los, Jenna (J); Wied, Heather M (HM); Gordon, Barry (B); Kossoff, Eric H (EH); Gao, Qian (Q); Vining, Eileen P (EP);

Affiliation: Department of Neurology, John Hopkins Hospital, Baltimore 21287, USA. dboatma(-atsign-)jhmi.edu

Grants: R01-DC005645 (Agency:NIDCD NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Epilepsia (Epilepsia), published in United States. (Language: eng)

Reference: 2008-Jun; vol 49 (issue 6) : pp 1018-26

Dates: Created 2008/06/16; Completed 2008/06/25;

PMID: 18266745, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Attention - physiology Auditory Cortex - physiopathology Auditory Perceptual Disorders - diagnosis; physiopathology Brain Stem - physiopathology Child Contingent Negative Variation - physiology Diagnosis, Differential Dominance, Cerebral - physiology Electroencephalography Epilepsy, Rolandic - diagnosis; physiopathology Evoked Potentials, Auditory - physiology

Evoked Potentials, Auditory, Brain Stem - physiology Female Hearing Tests Humans Male Perceptual Masking - physiology Reaction Time - physiology Signal Processing, Computer-Assisted Speech Perception - physiology Speech Reception Threshold Test Temporal Lobe - physiopathology

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