Research article summary (published 13 Mar 1991):

[The influence of autonomic diabetic neuropathy and human atrial natriuretic peptide on adrenal gland function in postural changes]

(Einfluss der autonomen diabetischen Neuropathie und des humanen atrialen natriuretischen Peptids auf das Verhalten der Nebennierenfunktion bei Anderung der Körperhaltung.)

Full Abstract

To investigate the influence of postural changes on plasma renin activity (PRA), plasma levels of human atrial natriuretic peptide (hANP) and on aldosterone in diabetes mellitus and autonomic neuropathy, ten patients with diabetes mellitus and autonomic neuropathy and ten patients with diabetes mellitus but without autonomic neuropathy were studied. Ten healthy subjects served as controls. Patients and controls were in supine position for 60 minutes, then changed posture sequentially to sitting (90 minutes) and to upright position (15 minutes). In controls, PRA was increased upon sitting and in the upright position, while hANP was decreased. Patients with autonomic neuropathy differed from controls in impaired renin stimulation, whereas in patients without autonomic neuropathy PRA responses to postural changes were only slightly decreased. In both groups of patients, the normal hANP responsiveness to postural changes was lacking. There were no differences in aldosterone levels between patients and controls. In patients with high basal hANP levels due to elevated systolic blood pressure renin responses to postural changes were decreased in comparison to those patients with low basal hANP levels. Thus, in patients with diabetes mellitus increased hANP levels which are not decreased in response to upright standing may contribute to the development of hyporeninism and its sequelae.

Author information

Author/s: Haak, T (T); Jungmann, E (E); Neumann, M (M); Zeuzem, S (S); Schwietzer, G (G); Reschke, B (B); Althoff, P H (PH); Schöffling, K (K);

Affiliation: Abteilung für Endokrinologie, Zentrum der Inneren Medizin, Johann-Wolfgang-Goethe-Universität, Frankfurt am Main.

Journal and publication information

Publication Type: English Abstract; Journal Article

Journal: Medizinische Klinik (Munich, Germany : 1983) (Med Klin (Munich)), published in GERMANY. (Language: ger)

Reference: 1991-Mar; vol 86 (issue 3) : pp 138-41, 171

Dates: Created 1991/06/27; Completed 1991/06/27; Revised 2006/11/15;

PMID: 1827874, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Aldosterone - blood Atrial Natriuretic Factor - blood Autonomic Nervous System Diseases - blood; physiopathology Diabetic Neuropathies - blood; physiopathology

Humans Middle Aged Posture Renin - blood Renin-Angiotensin System - physiology

Associated Chemicals: Aldosterone (52-39-1) ; Atrial Natriuretic Factor (85637-73-6) ; Renin (EC 3.4.23.15)

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