Differential effects of neurotoxin-induced lesions of the basolateral amygdala and central nucleus of the amygdala on lithium-induced conditioned disgust reactions and conditioned taste avoidance.

Full Abstract

When rats are intraorally exposed to saccharin solution that has previously been paired with lithium chloride (LiCl), they display Pavlovian conditioned disgust reactions. When exposed to LiCl-paired saccharin solution by bottle, they display suppressed instrumental approach to the bottle resulting in suppressed consumption. The present experiments demonstrated that while neither neurotoxin-induced lesions of the basolateral amygdala (BLA) nor the central nucleus of the amygdala (CeA) attenuated the display of Pavlovian conditioned disgust reactions, lesions of the BLA (but not the CeA) attenuated instrumental conditioned avoidance of the taste. The results are discussed in light of current models of the role of the amygdala in aversive learning.

Learn Faster Today Improve your study skills

Author information

Author/s: Rana, Shadna A (SA); Parker, Linda A (LA);

Affiliation: Department of Psychology, Wilfrid Laurier University, Waterloo, ON, Canada.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Behavioural brain research (Behav Brain Res), published in Netherlands. (Language: eng)

Reference: 2008-Jun; vol 189 (issue 2) : pp 284-97

Dates: Created 2008/04/04; Completed 2008/07/09;

PMID: 18299156, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Amygdala - drug effects; physiology
Animals
Association Learning - physiology
Avoidance Learning - drug effects; physiology
Conditioning, Classical - drug effects; physiology
Excitatory Amino Acid Agonists - pharmacology
Flavoring Agents

Flavoring Agents
Lithium Chloride
Male
Nausea - chemically induced; physiopathology; psychology
Rats
Rats, Sprague-Dawley
Taste - drug effects; physiology

Associated Chemicals: Excitatory Amino Acid Agonists (0) ; Flavoring Agents (0) ; Lithium Chloride (7447-41-8)

These are the highest related articles currently in the database:

See 100+ related articles.