The associations between psychosocial stress and the frequency of illness, and innate and adaptive immune function in children.

Full Abstract

OBJECTIVE:
Family processes have a substantial impact on children's social and emotional well-being, but little is known about the effects of family stress on children's physical health. To begin to identify potential links between family stress and health in children, we examined associations between specific aspects of family psychosocial stress and the frequency of illnesses in children, measures of innate and adaptive immune function, and human herpesvirus 6 (HHV-6) reactivation.

STUDY DESIGN:
Prospective study of 169 ambulatory school-age children and parents. Parents completed multiple assessments of stress at 7 sequential six-month visits and maintained weekly illness diaries for their children over three years using a thermometer to record fever. Children had blood obtained for HHV-6 and immune function studies at each visit including natural killer (NK) cell function and the percentage of CD4 and CD8 cells associated with immune control of cytomegalovirus (CMV).

RESULTS:
Parental psychiatric symptoms were associated with a higher frequency of illnesses:
for each 1 U increase in symptom score children had an increased 1-year rate of total illnesses of 40% (rate ratio, 1.40; 95% CI, 1.06-1.85) and febrile illnesses of 77% (rate ratio, 1.77, 95% CI, 1.00-3.13). Parental psychiatric symptom scores were also associated with enhanced NK cell function (estimate, 0.15; 95% CI, 0.05-0.26) and increased percentages of CD8+CD28-CD57+ cells in the blood of CMV seropositive children (estimate, 2.57; 95% CI, 0.36-4.79). HHV-6 reactivation was not detected.

CONCLUSIONS:
There is an association between specific psychosocial stress exposure and rates of illness and immune function in normally developing children.

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Author information

Author/s: Caserta, Mary T (MT); O'Connor, Thomas G (TG); Wyman, Peter A (PA); Wang, Hongyue (H); Moynihan, Jan (J); Cross, Wendi (W); Tu, Xin (X); Jin, Xia (X);

Affiliation: Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. mary_caserta(-atsign-)urmc.rochester.edu

Grants: 1 UL1 RR024160-01 (Agency:United States NCRR) ; 5 MO1 RR00044 (Agency:United States NCRR) ; R01 HD 38938 (Agency:United States NICHD)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Brain, behavior, and immunity (Brain Behav Immun), published in United States. (Language: eng)

Reference: 2008-Aug; vol 22 (issue 6) : pp 933-40

Dates: Created 2008/07/08; Completed 2008/08/12;

PMID: 18308510, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Child
Child, Preschool
Cytomegalovirus - immunology
Family Health
Female
Herpesvirus 6, Human - immunology
Humans

Immunity - physiology
Immunity, Natural - physiology
Killer Cells, Natural - immunology
Male
Parent-Child Relations
Parents - psychology
Prospective Studies
Questionnaires
Stress, Psychological - immunology

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