Obsessive-compulsive disorder: influence of age at onset on comorbidity patterns.

Full Abstract

PURPOSE: This study investigates the influence of age at onset of OCS on psychiatric comorbidities, and tries to establish a cut-off point for age at onset. METHODS: Three hundred and thirty OCD patients were consecutively recruited and interviewed using the following structured interviews: Yale-Brown Obsessive Compulsive Scale; Yale Global Tic Severity Scale and the Structured Clinical Interview for DSM-IV. Data were analyzed with regression and cluster analysis. RESULTS: Lower age at onset was associated with a higher probability of having comorbidity with tic, anxiety, somatoform, eating and impulse-control disorders. Longer illness duration was associated with lower chance of having tics. Female gender was associated with anxiety, eating and impulse-control disorders. Tic disorders were associated with anxiety disorders and attention-deficit/hyperactivity disorder. No cut-off age at onset was found to clearly divide the sample in homogeneous subgroups. However, cluster analyses revealed that differences started to emerge at the age of 10 and were more pronounced at the age of 17, suggesting that these were the best cut-off points on this sample. CONCLUSIONS: Age at onset is associated with specific comorbidity patterns in OCD patients. More prominent differences are obtained when analyzing age at onset as an absolute value.

Author information

Author/s: de Mathis, Maria Alice (MA); do Rosario, Maria Conceição (MC); Diniz, Juliana Belo (JB); Torres, Albina Rodrigues (AR); Shavitt, Roseli Gedanki (RG); Ferrão, Ygor Arzeno (YA); Fossaluza, Victor (V); de Bragança Pereira, Carlos Alberto (CA); Miguel, Eurípedes Constantino (EC);

Affiliation: Department of Psychiatry, University of Sao Paulo Medical School, Rua Dr. Ovídio Pires de Campos, 785, 05403-010 São Paulo, SP, Brazil. alicedemathis(-atsign-)gmail.com

Journal and publication information

Publication Type: Journal Article

Journal: European psychiatry : the journal of the Association of European Psychiatrists (Eur Psychiatry), published in France. (Language: eng)

Reference: 2008-Apr; vol 23 (issue 3) : pp 187-94

Dates: Created 2008/03/24; Completed 2008/06/17;

PMID: 18329252, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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