Rapid report on methodology: does loss to follow-up in a cohort study bias associations between early life factors and lifestyle-related health outcomes?

Full Abstract

PURPOSE:
To examine the consequences of non-response in a follow-up survey for associations between early-life factors and lifestyle-related health outcomes in adulthood.

METHODS:
In a cohort of 11532 Danish men born in 1953 we had nearly complete follow-up in the National Patient Register, but only 66% of 9507 eligible cohort members participated in a follow-up survey, in 2004. We examined whether characteristics measured early in life and discharge from hospital for alcohol abuse or tobacco-related lung diseases, were associated with survey response. Associations between the early-life characteristics and these two health outcomes were calculated in the entire cohort and among responders, and the effect of non-response was described by a Relative Odd Ratio (ROR=OR(responders)/OR(entire cohort)).

RESULTS:
A low response rate at age 50 years was related to having a single mother at birth, low educational attainment at age 18, and low cognitive function at ages 12 and 18. The risk of alcohol overuse and tobacco-related diseases was also highest among non-responders. However, the associations between early-life characteristics and the outcomes were nearly the same in responders as in the entire cohort.

CONCLUSIONS:
Although non-responders differed from responders in terms of early-life exposures and incidence of the lifestyle-related outcomes, we found no overt effects of this on the exposure-risk associations.

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Author information

Author/s: Osler, Merete (M); Kriegbaum, Margit (M); Christensen, Ulla (U); Holstein, Bjørn (B); Nybo Andersen, Anne-Marie (AM);

Affiliation: Department of Epidemiology, University of Southern Denmark. m.osler(-atsign-)pubhealth.ku.dk

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Annals of epidemiology (Ann Epidemiol), published in United States. (Language: eng)

Reference: 2008-May; vol 18 (issue 5) : pp 422-4

Dates: Created 2008/04/24; Completed 2008/06/19; Revised 2008/06/23;

PMID: 18329893, status: MEDLINE (last retrieval date: 11/6/2008)

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