Effect of schedule of reinforcement on cue-elicited reinstatement of cocaine-seeking behavior.

Full Abstract

Cocaine-associated cues can elicit incentive motivational effects that drive cocaine-seeking behavior and contribute to relapse. The extinction/reinstatement model is commonly used to measure these effects in animals. This study examined the influence of training and testing schedules of reinforcement on cue-elicited reinstatement. Lever presses during training resulted in cues and cocaine (0.75 mg/kg/IV) on either continuous or partial reinforcement schedules [fixed ratio (FR) 1 or 11, variable ratio (VR) 5 or 11]. Animals then underwent extinction training, followed by a test for cue-elicited reinstatement of extinguished cocaine-seeking behavior by response-contingent cue presentations on either a continuous (FR 1) or a partial reinforcement schedule (FR 11). Partial reinforcement during training resulted in higher response rates during cue-elicited reinstatement relative to continuous reinforcement. In contrast, delivery of cues on a continuous reinforcement schedule during testing yielded higher response rates relative to delivery on a partial reinforcement schedule. Finally, the shift from a partial to a continuous reinforcement schedule across training and testing phases did not alter response rates. These findings provide important information for choosing parameters for reinstatement of drug-seeking behavior that would allow the most sensitive method to detect changes in response rate after an experimental manipulation.

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Author information

Author/s: Acosta, Jazmin I (JI); Thiel, Kenneth J (KJ); Sanabria, Federico (F); Browning, Jenny R (JR); Neisewander, Janet L (JL);

Affiliation: Department of Psychology, Arizona State University, Tempe, Arizona, USA.

Grants: DA11064 (Agency:United States NIDA)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Behavioural pharmacology (Behav Pharmacol), published in England. (Language: eng)

Reference: 2008-Mar; vol 19 (issue 2) : pp 129-36

Dates: Created 2008/03/11; Completed 2008/06/17;

PMID: 18332677, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Cocaine - administration & dosage
Cocaine-Related Disorders - psychology
Cues
Dose-Response Relationship, Drug
Drug Administration Schedule
Extinction, Psychological - drug effects

Extinction, Psychological - drug effects
Male
Motivation
Rats
Rats, Sprague-Dawley
Reinforcement Schedule
Self Administration

Associated Chemicals: Cocaine (50-36-2)

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