Fingerprint profile of Ginkgo biloba nutritional supplements by LC/ESI-MS/MS.

Full Abstract

Ginkgo biloba is one of the most popular herb nutrition supplements, with terpene lactones and flavonoids being the two major active components. A fingerprint profile method was developed using a capillary HPLC/MS method which can identify more than 70 components from the G. biloba product. The method allows the flavonoids and terpene lactones to be detected simultaneously and information of both the parent ion and its fragmentation can be obtained in just one HPLC/MS run. Targeted post-acquisition analysis allows mass spectrometric information regarding the identification of flavonoid components to be easily distinguished from other data, however the same approach for terpene lactones was less successful due to dimer formation and requires further development. The fingerprint profiles of five commercial G. biloba nutritional supplements were obtained and compared; variation of some components among the samples was observed and fortification could be detected. In the quality control analysis of the G. biloba product this method could be viewed as complementary to specific quantitative analysis of some bioactive components of the herb.

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Author information

Author/s: Ding, S (S); Dudley, E (E); Plummer, S (S); Tang, J (J); Newton, R P (RP); Brenton, A G (AG);

Affiliation: Biomolecular Analysis Mass Spectrometry Facility, University of Wales Swansea, Singleton Park, Swansea, UK.

Journal and publication information

Publication Type: Journal Article

Journal: Phytochemistry (Phytochemistry), published in United States. (Language: eng)

Reference: 2008-May; vol 69 (issue 7) : pp 1555-64

Dates: Created 2008/04/21; Completed 2008/07/25;

PMID: 18342344, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Chromatography, High Pressure Liquid - methods
Dietary Supplements - analysis
Flavonoids - analysis; chemistry
Ginkgo biloba - chemistry

Molecular Structure
Spectrometry, Mass, Electrospray Ionization - methods
Tandem Mass Spectrometry - methods
Terpenes - analysis; chemistry

Associated Chemicals: Flavonoids (0) ; Terpenes (0)

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