Research article summary (published 28 Feb 2008):

The evidence for hippocampal long-term potentiation as a basis of memory for simple tasks.

Full Abstract

Long-term potentiation (LTP) is the enhancement of postsynaptic responses for hours, days or weeks following the brief repetitive afferent stimulation of presynaptic afferents. It has been proposed many times over the last 30 years to be the basis of long-term memory. Several recent findings finally supported this hypothesis: a) memory formation of one-trial avoidance learning depends on a series of molecular steps in the CA1 region of the hippocampus almost identical to those of LTP in the same region; b)hippocampal LTP in this region accompanies memory formation of that task and of another similar task. However, CA1 LTP and the accompanying memory processes can be dissociated, and in addition plastic events in several other brain regions(amygdala, entorhinal cortex, parietal cortex) are also necessary for memory formation of the one-trial task, and perhaps of many others.

Author information

Author/s: Izquierdo, Iván (I); Cammarota, Martín (M); Da Silva, Weber C (WC); Bevilaqua, Lia R M (LR); Rossato, Janine I (JI); Bonini, Juliana S (JS); Mello, Pamela (P); Benetti, Fernando (F); Costa, Jaderson C (JC); Medina, Jorge H (JH);

Affiliation: Centro de Memória, Instituto de Pesquisas Biomédicas, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil. izquier(-atsign-)terra.com.br

Journal and publication information

Publication Type: Journal Article

Journal: Anais da Academia Brasileira de Ciências (An Acad Bras Cienc), published in Brazil. (Language: eng)

Reference: 2008-Mar; vol 80 (issue 1) : pp 115-27

Dates: Created 2008/03/17; Completed 2008/09/11;

PMID: 18345380, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Avoidance Learning - physiology Hippocampus - physiology Humans

Humans Long-Term Potentiation - physiology Memory - physiology Rats

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