Microstructural integrity of the corpus callosum linked with neuropsychological performance in adolescents.

Full Abstract

BACKGROUND:
Diffusion tensor imaging (DTI) has revealed microstructural aspects of adolescent brain development, the cognitive correlates of which remain relatively uncharacterized.

METHODS:
DTI was used to assess white matter microstructure in 18 typically developing adolescents (ages 16-18). Fractional anisotropy (FA) and mean diffusion (MD) were evaluated within the splenium and body of the corpus callosum in relation to cognitive performance.

RESULTS:
Visuospatial construction abilities were associated with white matter integrity in both the splenium and body of the corpus callosum, while only splenium integrity was associated with language and psychomotor function.

CONCLUSION:
Results suggest that, for typically developing adolescents, white matter coherence positively relates to visuospatial, psychomotor, and language skills. These findings may have implications for the cognitive functioning of clinical populations in which typical white matter development is altered.

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Author information

Author/s: Fryer, Susanna L (SL); Frank, Lawrence R (LR); Spadoni, Andrea D (AD); Theilmann, Rebecca J (RJ); Nagel, Bonnie J (BJ); Schweinsburg, Alecia D (AD); Tapert, Susan F (SF);

Affiliation: San Diego State University/University of California-San Diego, Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Court, San Diego, CA 92120, USA.

Grants: AA13419 (Agency:United States NIAAA) ; DA021182 (Agency:United States NIDA) ; DA15228 (Agency:United States NIDA) ; MH064729 (Agency:United States NIMH) ; R01 DA021182-01 (Agency:United States NIDA) ; T32 AA013525 (Agency:United States NIAAA)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

Journal: Brain and cognition (Brain Cogn), published in United States. (Language: eng)

Reference: 2008-Jul; vol 67 (issue 2) : pp 225-33

Dates: Created 2008/06/09; Completed 2008/08/22;

PMID: 18346830, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Anisotropy
Aptitude - physiology
Cognition - physiology
Corpus Callosum - anatomy & histology
Diffusion Magnetic Resonance Imaging
Female
Frontal Lobe - anatomy & histology

Frontal Lobe - anatomy & histology
Humans
Image Processing, Computer-Assisted
Inhibition (Psychology)
Male
Nerve Net - anatomy & histology
Neuropsychological Tests
Reference Values

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