Abietane diterpenoids from Clerodendrum bungei.

Full Abstract

Five new naturally occurring abietane diterpenoids (1-5) along with three known diterpenoids (6-8) were isolated from an acetone-soluble extract of the roots of Clerodendrum bungei. The structures of the new compounds were elucidated on the basis of spectroscopic analysis and chemical methods. In addition, all compounds were evaluated for cytotoxic activity against the cultured B16 (murine melanoma), HGC-27 (human gastric), and HEK-293 (human epithelial kidney) cell lines. Uncinatone (7) exhibited moderate cytotoxicity, inhibited cell proliferation, and induced cell-cycle G(2)/M phase arrest.

Author information

Author/s: Liu, Shanshan (S); Zhu, Huilin (H); Zhang, Shuwei (S); Zhang, Xiaohui (X); Yu, Qiang (Q); Xuan, Lijiang (L);

Affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Zhangjiang Hi-Tech Park, Shanghai, PR China.

Journal and publication information

Publication Type: Journal Article

Journal: Journal of natural products (J Nat Prod), published in United States. (Language: eng)

Reference: 2008-May; vol 71 (issue 5) : pp 755-9

Dates: Created 2008/05/26; Completed 2008/07/28;

PMID: 18348535, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: 18 Feb 2009 00:00:00)

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