Diffusion-weighted magnetic resonance imaging at 3.0 Tesla in alcohol intoxication.

Full Abstract

Acute alcohol intake has pronounced effects on brain function. However, the exact mechanism of action is unclear. Diffusion Magnetic Resonance Imaging (dwMRI) can detect subtle changes in microstructural neural states. Here we tested if dwMRI can detect such changes during alcohol intoxication. We used high-field dwMRI in four healthy subjects at different blood alcohol concentration (0.0 g/L, 0.3 g/L, 0.6 g/L and 1.0 g/L). Although neuropsychological performances declined markedly, no changes in diffusion parameters emerged. First, this finding argues against alcohol-induced diffuse changes of microstructural state and in favour of more specific, possibly receptor-mediated actions of alcohol on brain function. Second, processes involving neurotransmitters that are primarily linked to cognitive function might not be viewable with high-field diffusion MRI.

Author information

Author/s: Duning, Thomas (T); Kugel, Harald (H); Menke, Ricarda (R); Knecht, Stefan (S);

Affiliation: University Hospital of Münster, Department of Neurology, Albert-Schweitzer-Str. 33, 48149 Münster, Germany. duningt(-atsign-)uni-muenster.de

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Psychiatry research (Psychiatry Res), published in Ireland. (Language: eng)

Reference: 2008-May; vol 163 (issue 1) : pp 52-60

Dates: Created 2008/05/12; Completed 2008/08/22;

PMID: 18348904, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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