Evaluation of the APP23-model for Alzheimer's disease in the odour paired-associate test for hippocampus-dependent memory.

Full Abstract

The APP23 model is a transgenic mouse model for Alzheimer's disease. Cognitive performance in the APP23-model was assessed by Morris Water Maze (MWM) and passive avoidance learning, but the latter failed to show any difference between the genotypes. In search of a non-spatial alternative for assessment of hippocampus-dependent memory, we evaluated an odour paired-associate test, which is based on learning an association between two sets of odours. The protocol includes a shaping phase, in which the animals learn to dig up a reward, a preliminary training phase and a training phase, where the actual association is learned. Subsequently, mice are tested for transitive inference and subjected to a symmetry test. Impairment was seen in the APP23 mice, in comparison with wild type mice, in training; however, both groups failed the transitivity and symmetry test. Possible explanations for this discrepancy with earlier published results are the advanced age of the mice or the C57Bl/6J background, in which the model was established.

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Author information

Author/s: Van Dijck, Annemie (A); Vloeberghs, Ellen (E); Van Dam, Debby (D); Staufenbiel, Matthias (M); De Deyn, Peter Paul (PP);

Affiliation: Laboratory of Neurochemistry & Behaviour, Institute Born-Bunge, University of Antwerp, Department of Biomedical Sciences, Universiteitsplein 1, Wilrijk, Belgium.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Behavioural brain research (Behav Brain Res), published in Netherlands. (Language: eng)

Reference: 2008-Jun; vol 190 (issue 1) : pp 147-51

Dates: Created 2008/04/18; Completed 2008/08/13;

PMID: 18359101, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Age Factors
Alzheimer Disease - genetics; pathology; physiopathology
Amyloid beta-Protein Precursor - genetics
Analysis of Variance
Animals
Association Learning - physiology
Disease Models, Animal
Hippocampus - physiopathology
Humans

Humans
Maze Learning
Memory - physiology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Odors
Psychomotor Performance - physiology
Random Allocation

Associated Chemicals: Amyloid beta-Protein Precursor (0)

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