Does mild autonomic neuropathy affect atrial natriuretic factor regulation in diabetic hypertensive patients?

Full Abstract

The effect of postural changes on plasma atrial natriuretic factor (ANF) levels was investigated in 16 diabetic hypertensives (eight with and eight without mild autonomic neuropathy) and in 10 hypertensives. The presence of renal damage or secondary hypertension was excluded. All diabetic patients were in good metabolic control. In upright position, the mean levels of plasma ANF were of 23.1 +/- 7.6 pg/mL in neuropathic diabetic hypertensives, 24.2 +/- 8.3 pg/mL in diabetic hypertensives, and 21.6 +/- 6.7 in essential hypertensives. Percentage decrease observed after the assumption of supine position was 47 +/- 18, 50 +/- 10, and 46 +/- 13, respectively. No significant difference was found between hypertensives and diabetic hypertensives, even in the presence of mild autonomic neuropathy. Plasma ANF response to postural changes was similar in all groups.

Author information

Author/s: De Mattia, G (G); Laurenti, O (O); Bravi, C (C); Ferri, C (C); Bellini, C (C); De Angelis, C (C); Giarrizzo, C (C); Santucci, A (A); Balsano, F (F);

Affiliation: Fondazione Andrea Cesalpino, Università La Sapienza, Rome, Italy.

Journal and publication information

Publication Type: Journal Article

Journal: American journal of hypertension (Am J Hypertens), published in UNITED STATES. (Language: eng)

Reference: 1991-Oct; vol 4 (issue 10 Pt 1) : pp 832-5

Dates: Created 1992/01/17; Completed 1992/01/17; Revised 2009/02/24;

PMID: 1836132, status: MEDLINE (last retrieval date: 3/9/2009, IMS Date: 09 Mar 2009 00:00:00)

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