Research article summary (published 18 Feb 2008):

Evaluation of a neurodevelopmental model of schizophrenia--early postnatal PCP treatment in attentional set-shifting.

Full Abstract

Phencyclidine (PCP) was administered to male and female Lister hooded rats on postnatal days (PND) 7, 9 and 11. All PCP animals tested in adulthood (PND 53-93) showed deficits in cognitive flexibility, specifically in their ability to shift attentional set, compared to controls. This novel finding is reminiscent of the impairment observed in schizophrenia patients, and supports the validity of the early postnatal PCP regimen as a disease-like model.

Learn Faster Today      Improve your study skills

Author information

Author/s: Broberg, Brian Villumsen (BV); Dias, Rebecca (R); Glenthøj, Birte Yding (BY); Olsen, Christina Kurre (CK);

Affiliation: Department of Psychopharmacology, H. Lundbeck A/S, Ottiliavej 9, Valby, Denmark. bbs(-atsign-)lundbeck.com

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Behavioural brain research (Behav Brain Res), published in Netherlands. (Language: eng)

Reference: 2008-Jun; vol 190 (issue 1) : pp 160-3

Dates: Created 2008/04/18; Completed 2008/08/13;

PMID: 18367258, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Age Factors Animals Animals, Newborn Attention - drug effects Behavior, Animal - drug effects Discrimination (Psychology) - drug effects Disease Models, Animal Dose-Response Relationship, Drug Evaluation Studies as Topic

Evaluation Studies as Topic Female Male Odors Phencyclidine Pregnancy Rats Schizophrenia - chemically induced; physiopathology Sex Factors

Associated Chemicals: Phencyclidine (77-10-1)

Related articles

These are the highest related articles currently in the database:

• Impairment in perceptual attentional set-shifting following PCP administration: a rodent model of set-shifting deficits in schizophrenia. 27 Jan 2005
• PDE10A inhibition reverses subchronic PCP-induced deficits in attentional set-shifting in rats. 30 Jan 2005
• A preliminary investigation into the effects of antipsychotics on sub-chronic phencyclidine-induced deficits in attentional set-shifting in female rats. 13 Jan 2008
• Reversal of subchronic PCP-induced deficits in attentional set shifting in rats by sertindole and a 5-HT(6) receptor antagonist: comparison among antipsychotics. 17 Dec 2007
• Behavioural effects of neonatal lesions of the medial prefrontal cortex and subchronic pubertal treatment with phencyclidine of adult rats. 2 Jan 2006
• Sensitization to amphetamine, but not PCP, impairs attentional set shifting: reversal by a D1 receptor agonist injected into the medial prefrontal cortex. 7 Nov 2005
• Modelling prefrontal cortex deficits in schizophrenia: implications for treatment. 28 Feb 2008
• Prenatal exposure to an NMDA receptor antagonist, MK-801 reduces density of parvalbumin-immunoreactive GABAergic neurons in the medial prefrontal cortex and enhances phencyclidine-induced hyperlocomotion but not behavioral sensitization to methamphetamine in postpubertal rats. 4 Mar 2007

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.