Delayed aversive effects of high-dose fentanyl. Prevention by a polyamine-deficient diet.

Full Abstract

The present study aimed to examine the effects of an acute administration of the mu-opioid receptor fentanyl on affect as assessed by place-conditioning procedure in rats. We determined the affective properties of fentanyl not only immediately following its administration, but also 24h later. Experiments were performed using the dose of fentanyl (240 gamma/kg; four injections of 60 gamma/(ml kg) every 15 min, subcutaneously) for which secondary hyperalgesia has been previously described. Our results show that the acute administration of fentanyl display biphasic affective properties, with early rewarding and 24-h delayed aversive components. The 24-h delayed aversive effects of fentanyl were not observed in animals submitted to a polyamine-deficient diet, suggesting an NMDA-dependent mechanism.

Learn Faster Today Improve your study skills

Author information

Author/s: Pain, Laure (L); Oberling, Philippe (P); Mainsongeon, Maud (M); Moulinoux, Jacques-Philippe (JP); Simonnet, Guy (G);

Affiliation: INSERM U666 (GRERCA) and Hôpitaux Universitaires de Strasbourg, Faculty of Medicine, 11 rue Humann, Strasbourg, France. Laurepain(-atsign-)aol.com

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Behavioural brain research (Behav Brain Res), published in Netherlands. (Language: eng)

Reference: 2008-Jun; vol 190 (issue 1) : pp 119-23

Dates: Created 2008/04/18; Completed 2008/08/13;

PMID: 18378328, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Amines - metabolism
Analgesics, Opioid - administration & dosage
Animals
Behavior, Animal - drug effects
Conditioning, Operant - drug effects
Deficiency Diseases - prevention & control
Dose-Response Relationship, Drug
Drug Administration Schedule

Drug Administration Schedule
Fentanyl - administration & dosage
Male
Rats
Rats, Long-Evans
Reward
Spatial Behavior - drug effects
Time Factors

Associated Chemicals: Amines (0) ; Analgesics, Opioid (0) ; Fentanyl (437-38-7)

These are the highest related articles currently in the database:

See 100+ related articles.