BNP or NTproBNP? A clinician's perspective.

Full Abstract

Existing literature on two natriuretic peptides--B-type natriuretic peptide (BNP) and amino terminal pro-brain natriuretic peptide (NTproBNP)--is overwhelming. Both peptides are acknowledged markers for cardiac dysfunction. Most of the sources present data on either BNP or NTproBNP making the comparison difficult. This paper focuses on reviewing studies directly comparing two peptides in the setting of chronic and acute heart failure (HF) and coronary artery disease. Many concomitant diseases influence these two peptides to varying extent. These characteristics should be taken into consideration when interpreting results. For most practical purposes, BNP and NTproBNP are interchangeable, and can be used based on local preferences and availability. NTproBNP seems to be more advantageous for diagnosing mild HF or asymptomatic left ventricular dysfunction.

Author information

Author/s: Steiner, Johannes (J); Guglin, Maya (M);

Affiliation: University of South Florida, United States.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Review

Journal: International journal of cardiology (Int J Cardiol), published in Netherlands. (Language: eng)

Reference: 2008-Sep; vol 129 (issue 1) : pp 5-14

Dates: Created 2008/08/19; Completed 2009/02/10;

PMID: 18378336, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Humans
Natriuretic Peptide, Brain - blood; physiology
Peptide Fragments - blood; physiology
Protein Precursors - blood; physiology
Ventricular Dysfunction, Left - blood; diagnosis

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Biological Markers (0) ; Peptide Fragments (0) ; Protein Precursors (0) ; pro-brain natriuretic peptide (1-76) (0) ; Natriuretic Peptide, Brain (114471-18-0)

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