Polysaccharides fraction isolated from ginkgo biloba folium: immunopharmacological properties.

Full Abstract

Many macromolecular compounds of vegetal polysaccharides type develop important immunostimulatory properties.

MATERIALS AND METHODS:
Crude macromolecular fraction was isolated from the leaves of Ginkgo biloba L. (codified as PGfol) harvested from Botanical Gardens of Iasi, Romania. The hot water extract was partially purified and submitted to chemical and immunopharmacological studies. The immunostimulatory activity of PGfol was further investigated by a series of tests on rats:
phagocytosis capacity of PMN cells by NBT test, serum complement activity and determination of the activity of splenic T-lymphocytes.

RESULTS:
PGfol has a good immunostimulatory activity which is equal or higher to Levamisole (positive control).

Learn Faster Today Improve your study skills

Author information

Author/s: Hancianu, Monica (M); Pavelescuz, M (M); Miron, Anca (A); Aprotosoaie, Ana Clara (AC); Grigorescu, Em (E); Lupusoru, Catalina (C); Stanescu, Ursula (U);

Affiliation: Department of Pharmacognosy, School of Pharmacy, "Gr.T. Popa" University of Medicine and Pharmacy, Iasi.

Journal and publication information

Publication Type: Comparative Study; Journal Article

Journal: Revista medico-chirurgicala? a Societa?t?ii de Medici s¸i Naturalis¸ti din Ias¸i (Rev Med Chir Soc Med Nat Iasi), published in Romania. (Language: eng)

Reference: -2007 Oct-Dec; vol 111 (issue 4) : pp 1070-3

Dates: Created 2008/04/07; Completed 2008/07/03;

PMID: 18389807, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adjuvants, Immunologic - pharmacology; therapeutic use
Animals
Disease Models, Animal
Ginkgo biloba - chemistry
Inflammation - chemically induced; drug therapy; immunology
Levamisole - pharmacology; therapeutic use
Phagocytosis - drug effects
Phytotherapy

Plant Extracts - pharmacology; therapeutic use
Plant Leaves
Polysaccharides - isolation & purification; pharmacology; therapeutic use
Rats
Rats, Wistar
Spleen - cytology; immunology
T-Lymphocytes - drug effects
Treatment Outcome

Associated Chemicals: Adjuvants, Immunologic (0) ; Plant Extracts (0) ; Polysaccharides (0) ; Levamisole (14769-73-4)

These are the highest related articles currently in the database:

See 100+ related articles.