Dietary agents for chemoprevention of prostate cancer.

Full Abstract

Prostate cancer (CaP) is the leading cause of cancer-related deaths in American men, responsible for over 29,000 deaths in the year 2007. Chemoprevention is a plausible and cost-effective approach to reduce cancer morbidity and mortality through inhibition of precancerous events before the occurrence of clinical disease. Indeed, CaP is an ideal candidate disease for chemopreventive intervention as it is typically diagnosed in the elderly population with a relatively slower rate of growth and progression. The potential of dietary substances to act as chemopreventive agents against CaP is increasingly appreciated. Further, epidemiological studies have identified significant correlations between CaP incidence and dietary habits. It is hoped that, combining the knowledge based on agents with targets, we will be able to build an armamentarium of naturally occurring chemopreventive substances that could prevent or slow down the development and progression of CaP. In this review, we have summarized the findings from clinical and preclinical studies on dietary agents including green tea, pomegranate, lupeol, fisetin, and delphinidin that are currently being investigated in our laboratory for their chemopreventive potential against CaP.

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Author information

Author/s: Syed, Deeba N (DN); Suh, Yewseok (Y); Afaq, Farrukh (F); Mukhtar, Hasan (H);

Affiliation: Department of Dermatology, University of Wisconsin, Medical Sciences Center, Madison, WI 53706, USA.

Journal and publication information

Publication Type: Journal Article; Review

Journal: Cancer letters (Cancer Lett), published in Ireland. (Language: eng)

Reference: 2008-Jul; vol 265 (issue 2) : pp 167-76

Dates: Created 2008/05/27; Completed 2008/07/31;

PMID: 18395333, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Flavonoids
Humans
Male
Prostatic Neoplasms - prevention & control
Punicaceae - chemistry
Triterpenes

Associated Chemicals: Antioxidants (0) ; Flavonoids (0) ; Triterpenes (0) ; fisetin (528-48-3) ; lupeol (545-47-1)

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