Research article summary (published 29 Apr 2008):

Pygopus and the Wnt signaling pathway: a diverse set of connections.

Full Abstract

Identification of Pygopus in Drosophila as a dedicated component of the Wg (fly homolog of mammalian Wnt) signaling cascade initiated many inquiries into the mechanism of its function. Surprisingly, the nearly exclusive role for Pygopus in Wg signal transduction in flies is not seen in mice, where Pygopus appears to have both Wnt-related and Wnt-independent functions. This review addresses the initial findings of Pygopus as a Wg/Wnt co-activator in light of recent data from both fly and mammalian studies. We compare and contrast the developmental phenotypes of pygopus mutants to those characterized for known Wg/Wnt transducers and explore the data regarding a role for mammalian Pygopus 2 in tumorigenesis. We further analyze the roles of the two conserved domains of Pygopus proteins in transcription, and propose a model for the molecular mechanism of Pygopus function in both Wg/Wnt signaling and Wnt-independent transcriptional regulation. (c) 2008 Wiley Periodicals, Inc.

Author information

Author/s: Jessen, Shannon (S); Gu, Bingnan (B); Dai, Xing (X);

Affiliation: Department of Biological Chemistry, University of California, Irvine, CA, USA.

Grants: 5 T32 CA09054 (Agency:NCI NIH HHS) ; K02-AR51482 (Agency:NIAMS NIH HHS) ; R01-AR47320 (Agency:NIAMS NIH HHS)

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review

Journal: BioEssays : news and reviews in molecular, cellular and developmental biology (Bioessays), published in United States. (Language: eng)

Reference: 2008-May; vol 30 (issue 5) : pp 448-56

Dates: Created 2008/04/16; Completed 2008/05/22; Revised 2008/11/21;

PMID: 18404694, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Amino Acid Sequence Animals Chromatin Assembly and Disassembly Drosophila - genetics; growth & development; metabolism Drosophila Proteins - genetics; metabolism Evolution, Molecular Female Genes, Insect Humans Intracellular Signaling Peptides and Proteins - deficiency; genetics; metabolism Male Mice Mice, Knockout

Models, Biological Molecular Sequence Data Mutation Neoplasms - etiology; genetics; metabolism Phenotype Proto-Oncogene Proteins - genetics; metabolism Sequence Homology, Amino Acid Signal Transduction Species Specificity Trans-Activators - genetics; metabolism Wnt Proteins - genetics; metabolism Wnt1 Protein beta Catenin - metabolism

Associated Chemicals: Drosophila Proteins (0) ; Intracellular Signaling Peptides and Proteins (0) ; Proto-Oncogene Proteins (0) ; Pygo1 protein, mouse (0) ; Trans-Activators (0) ; Wnt Proteins (0) ; Wnt1 Protein (0) ; beta Catenin (0) ; pygopus 2 protein, mouse (0) ; pygopus protein, Drosophila (0) ; wg protein, Drosophila (0)

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