Risk assessments for the insect repellents DEET and picaridin.

Full Abstract

For the use of topical insect repellents, DEET and picaridin, human health risk assessments were conducted for various population subgroups. Acute, subchronic, and chronic dermal exposures were examined. No-observed-effect-levels (NOELs) of 200, 300, and 100mg/kg body weight (BW) were used as endpoints for DEET for acute, subchronic, and chronic exposures, respectively. For picaridin, a NOEL of 2000 mg/kg BW/day for acute exposure and a NOEL of 200 mg/kg BW/day for subchronic and chronic exposures were used. Daily exposures to several population subgroups were estimated. Risks were characterized using the Margin of Exposure (MOE) method (NOEL divided by the estimated exposure), whereby estimated MOEs were compared to an MOE of 100. Estimates of daily exposures ranged from 2 to 59 mg/kg BW/day for DEET and 2 to 22 mg/kg BW/day for picaridin. Children had the lowest MOEs. However, none of the estimated exposures exceeded NOELs for either repellent. At 40% DEET for acute exposure, children < or = 12 years had MOEs below 100. For subchronic and chronic exposures children at > or = 25% DEET and at 15% picaridin had MOEs below 100. Therefore, we found no significant toxicological risks from typical usage of these topical insect repellents.

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Author information

Author/s: Antwi, Frank B (FB); Shama, Leslie M (LM); Peterson, Robert K D (RK);

Affiliation: Department of Land Resources and Environmental Sciences, Montana State University, 334 Leon Johnson Hall, Bozeman, MT 59717-3120, USA. frank.antwi(-atsign-)montana.edu

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal: Regulatory toxicology and pharmacology : RTP (Regul Toxicol Pharmacol), published in United States. (Language: eng)

Reference: 2008-Jun; vol 51 (issue 1) : pp 31-6

Dates: Created 2008/05/20; Completed 2008/07/31;

PMID: 18406029, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Administration, Cutaneous
Adolescent
Animals
Child
DEET - toxicity
Dose-Response Relationship, Drug
Environmental Exposure - adverse effects; analysis; statistics & numerical data
Female

Associated Chemicals: Insect Repellents (0) ; Piperidines (0) ; picaridin (0) ; DEET (134-62-3)

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