Role of fosB in behaviours related to morphine reward and spatial memory.

Full Abstract

The immediate early genes (IEGs) have been suggested to be implicated in mechanisms of addiction, as well as in learning and memory processes. fosB, which belongs to IEG, has been reported to have pleiotropic impact on response to psychoactive drugs, as well as motivational and stress-related behaviours. In the present study, we used mice with constitutive knock-out of fosB in order to study fosB role in mouse phenotype. We studied rewarding properties of morphine (10mg/kg i.p.) in conditioned place preference (CPP) paradigm. Additionally, we studied fosB role in spatial memory and spatial working memory using elevated plus maze model of spatial learning (EPMSL) and delayed non-match to place task (DNMTP). In further studies, locomotor, depressive-like and anxiety-like behaviours were measured. Rewarding effects of morphine in fosB -/- mice were abolished whereas spatial learning was impaired. On the other hand, we found no significant differences in locomotor activity, depression-like and anxiety-like behaviours. In summary, our results indicate that mice lacking fosB are less sensitive to rewarding properties of morphine and display spatial memory impairment and suggest involvement of fosB and its proteins in motivational aspects of reinforcers as well as in learning and memory processes.

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Author information

Author/s: Solecki, Wojciech (W); Krowka, Tomasz (T); Kubik, Jakub (J); Kaczmarek, Leszek (L); Przewlocki, Ryszard (R);

Affiliation: Department of Molecular Neuropharmacology, Institute of Pharmacology, Polish Academy of Science, 12 Smetna Street, 31-343 Krakow, Poland.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Behavioural brain research (Behav Brain Res), published in Netherlands. (Language: eng)

Reference: 2008-Jul; vol 190 (issue 2) : pp 212-7

Dates: Created 2008/04/28; Completed 2008/07/30;

PMID: 18407360, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analysis of Variance
Animals
Association Learning - drug effects; physiology
Conditioning, Classical - drug effects; physiology
Male
Maze Learning - drug effects; physiology
Memory, Short-Term - drug effects; physiology
Mice
Mice, Inbred BALB C

Mice, Inbred BALB C
Mice, Knockout
Morphine - pharmacology
Motivation
Motor Activity - drug effects; physiology
Narcotics - pharmacology
Proto-Oncogene Proteins c-fos - genetics; metabolism
Reinforcement (Psychology)
Spatial Behavior - drug effects; physiology

Associated Chemicals: Fosb protein, mouse (0) ; Narcotics (0) ; Proto-Oncogene Proteins c-fos (0) ; Morphine (57-27-2)

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